Applied Systems Biology Core

抽象应用系统生物学核心(ASBC) 密歇根·奥布莱恩肾脏翻译资源中心(MKTC)旨在提供有效的 为研究基地研究人员开发新的机械治疗方法的转译研究管道 急、慢性肾脏疾病(CKD)患者的治疗策略。 应用系统生物学核心(ASBC)的主要目标是通过以下方式成为这一进程的催化剂 为全基因组肾脏数据集的综合数据挖掘提供专家咨询服务。在过去的几年里 14年来，ASBC团队开发了一套独特的工具和技能，作为连接 MKTC研究实验室的领域专家具有深厚的生物学和临床知识 大规模分子和临床肾脏疾病数据集中的片段。酷睿支持多种 肾脏研究人员的研究努力，从NIH培训和职业发展奖励奖获得者， 独立调查人员和美国国立卫生研究院资助的多中心研究网络。 ASBC的主要目标是使调查人员能够挖掘和提取相关知识 来自人类肾脏疾病和模型系统的基因组级数据集，以支持他们的研究需求： (A)从全球分子角度了解肾脏的发育、功能和损伤； (B)确定从功能上界定的肾脏疾病类别及其进展的分子标记； (C)确定治疗重点的关键途径； (D)为有针对性的临床试验从功能上确定患者群体； (E)将试验参与者对治疗的分子反应映射回途径和模型系统。 为了实现这一目标，ASBC向区域、国家和全球提供了一套独特的工具和技能 肾脏研究社区。核心的具体职能将是协助调查人员将 在其专注、假设驱动的研究中提供丰富的遗传和分子数据集，以集中这些研究 关于人类的疾病相关机制。这将通过两层方法实现，其中 ASBC团队使用一套数据挖掘和可视化工具提供个性化搜索策略 将研究基地的研究人员与从人类和模型数据集收集的分子洞察力联系起来。 交互式共享数据挖掘将由系统生物学家-生物医学/临床医生科学家研究执行 使用交互式或半结构化工作流的团队。同时，ASBC将采用标准化和 用于半监督数据挖掘的肾脏疾病大规模数据集的容器化工作流 经验丰富的中心调查人员。 ASBC将作为一个双向翻译机器，驱动基础和临床之间的互动 科学家致力于迅速发现和实施肾脏疾病的新见解和治疗方法。

ABSTRACT - APPLIED SYSTEMS BIOLOGY CORE (ASBC) The Michigan O'Brien Kidney Translational Resource Center (MKTC) aims to provide an effective translational research pipeline for research base investigators to develop novel, mechanistic treatment strategies for patients with acute and chronic kidney diseases (CKDs). The Primary Goal of the Applied Systems Biology Core (ASBC) is to be the catalyst of this process by providing expert consulting services for integrative data mining of genome wide renal data sets. During the last 14 years, the ASBC team has developed a unique set of tools and skills to serve as the bridge connecting the deep biological and clinical knowledge of the domain experts in the MKTC Research labs with the relevant segments in large-scale molecular and clinical renal disease data sets. The Core supports a wide range of research efforts by kidney researchers ranging from NIH training and career development grant awardees, independent investigators and NIH-funded multicenter research networks. The main objective of the ASBC is to empower investigators to mine and extract pertinent knowledge from genome-scale data sets from human kidney disease and model systems in support of their research needs: (a) Understand kidney development, function and injury in global molecular terms; (b) Define molecular markers of functionally defined renal disease categories and their progression; (c) Identify critical pathways for therapeutic focus; (d) Functionally define patient populations for targeted clinical trials; (e) Mapping molecular responses to treatments in trial participants back to pathways and model systems. To meet this objective, the ASBC provides a unique set of tools and skills to the reginal, national and global Kidney Research Community. Specific Functions of the Core will be to assist investigators in integrating the rich genetic and molecular data sets in their focused, hypothesis driven research to concentrate these studies on human, disease-associated mechanisms. This will be implemented with a two-tiered approach with the ASBC team providing individualized search strategies using a suite of data mining and visualization tools to link the research base investigators with molecular insights gleaned from human and model data sets. Interactive shared data-mining will be performed by a systems biologist–biomedical/clinician scientist research team using interactive or semi-structured work flows. In parallel, ASBC will employ standardized and containerized workflows for large-scale data sets of kidney disease for semi-supervised data mining by experienced center investigators. The ASBC will serve as a bi-directional translational machine driving interactions between basic and clinical scientists towards the rapid discovery and implementation of novel insights and therapies for kidney diseases.