ASSESSING THE EVOLVING IMPACT OF EARLY LIFE EXPOSURES ON CHILD PHYSICAL HEALTH AND NEURODEVELOPMENT

项目概要/描述 一个健康的孩子如何成长？每个父母都会问这个问题，简单的问题掩盖了复杂的本质 儿童的发展，使光的不同环境因素和变量，塑造一个孩子的 新兴的身体健康和神经发育。从概念开始，并在整个过程中加速 童年和青春期，我们独特的环境暴露和社会经历塑造了我们的行为， 影响我们的健康，影响我们发展认知技能和能力。它们并不是独立的实体， 身体健康和神经发育的各个方面在一个双向反馈循环中动态地一起进化 促进健康或迅速恶化的结果。在这个周期的每个阶段，影响孩子的因素 (e.g.,睡眠，化学品暴露，歧视），他们的家庭（例如，家庭社会人口特征）， 以及它们的邻域（例如，邻里安全、学校质量）可以改善健康或加速衰退。 在过去的两年里，COVID-19大流行给几乎每一个 儿童和家庭生活的各个方面，对低收入、种族和族裔少数群体的影响尤为严重 家庭ECHO队列中公共卫生反应的差异提供了一个重要的机会， 了解这些多层次的因素，包括健康的社会决定因素（SDoH），如何调节儿童 身体健康和神经发育。利用ECHO队列并采取团队科学方法， 这项提案旨在了解儿童神经发育与两个紧迫的公众问题之间的动态关系。 健康挑战：儿童哮喘和肥胖症;以及特定多水平调节剂（化学 暴露、儿童睡眠、身体活动和关键SDoH因素）。我们将研究：1.如何孩子 神经发育和身体健康结果，特别是哮喘和肥胖是由化学物质， 生物和社会环境暴露; 2.身体健康和神经发育如何共同发展， 在整个童年时期相互加强; 3.如何在孩子、家庭和邻里之间生活体验 背景，包括SDoH，中度神经发育结果;和4.这些关系是如何 受COVID-19大流行的影响，不同种族、民族和社会经济层面的情况各不相同。通过 一个全面的计划，加强多样化的观点（PEDP），我们采取了一个有意识的方法，包括 造成差异的社会、心理和经济不平等、约束和行为规范 在神经发育和儿童身体健康方面的作用。以获取和包容的核心原则，我们将重新- 入组我们的队列研究中心（RESONANCE），该研究中心包括>1650个特征良好的家庭-儿童二元组， 罗得岛不同的社会人口背景。使用新型远程数据收集和移动的 实验室，我们将解决传统的障碍，研究参与和访问，同时确保遵守和高 所有核心要素和生物样本的数据质量。我们以解决方案为导向的研究成果将 对卫生干预措施和公共政策指导产生直接和有意义的影响。

PROJECT SUMMARY / DESCRIPTION How does a healthy child grow? Asked by every parent, the simplicity of this question masks the complex nature of child development and makes light of the diverse environmental factors and variables that shape a child’s emerging physical health and neurodevelopment. Beginning at conception and accelerating throughout childhood and adolescence, our unique environmental exposures and social experiences shape our behaviors, impact our health, and influence our developing cognitive skills and abilities. Far from being distinct entities, aspects of physical health and neurodevelopment evolve dynamically together in a bi-directional feedback cycle that promotes healthy or rapidly worsening outcomes. At every stage of this cycle, factors that affect the child (e.g., sleep, chemical exposures, discrimination), their family (e.g., family sociodemographic characteristics), and their neighborhood (e.g., neighborhood safety, school quality) can improve health or accelerate decline. Over the past two years, the COVID-19 pandemic has ushered in widespread disruptions to almost every aspect of a child and family’s life, with disproportionate impacts on lower-income, and racial and ethnic minority families. Differences in public health responses across the ECHO Cohort offer an important opportunity to understand how these multi-level factors, including social determinants of health (SDoH), have moderated child physical health and neurodevelopment. Leveraging the ECHO Cohort and taking a team science approach, this proposal aims to understand the dynamic relationships that link child neurodevelopment and two pressing public health challenges: pediatric asthma and obesity; and the influence of specific multi-level moderators (chemical exposures, child sleep, physical activity, and key SDoH factors). We will examine: 1. How child neurodevelopment and physical health outcomes, specifically asthma, and obesity are shaped by chemical, biological, and social environmental exposures; 2. How physical health and neurodevelopment co-develop and reinforce each other throughout childhood; 3. How lived experiences across the child, family, and neighborhood contexts, including SDoH, moderate neurodevelopmental outcomes; and 4. How these relationships have been changed by the COVID-19 pandemic and varied across racial, ethnic, and socioeconomic dimensions. Through a comprehensive Plan for Enhancing Diverse Perspectives (PEDP), we take an intentional approach to include the social, psychosocial, and economic inequalities, constraints, and behavioral norms that underlie disparities in neurodevelopment and child physical health outcomes. With core tenets of access and inclusion, we will re- enroll our Cohort Study Site (RESONANCE) comprising >1650 well-characterized family-child dyads from diverse sociodemographic backgrounds across Rhode Island. Using novel remote data collection and mobile labs, we will address traditional barriers to research participation and access while ensuring adherence and high data quality across all core elements and biospecimens. Outcomes from our solutions-oriented research will have a direct and meaningful impact on health interventions and public policy guidance.