International Society for Magnetic Resonance in Medicine (ISMRM) workshop on WHATEVER: WHite Matter, Analysis, Translation, Experimental Validation, Evaluation, and Reproducibility

项目摘要 中枢神经系统（CNS）疾病是一个重要的公共卫生和经济问题， 近三分之一的美国人在生命的某个阶段，每年的成本超过5000亿美元。病理学上， 白色物质的完整性在几乎所有的人类神经疾病/损伤中都受到损害。 定量MRI（qMRI）方法有望改善白色物质的诊断和监测 紊乱尽管在复杂的qMRI方法的开发方面取得了很大进展，但它们在临床上的应用仍然是有限的。 还处于初期阶段这是开发和建立白色qMRI最佳实践的关键时刻 物质失调，研究人员必须走到一起分享知识，绘制下一个 qMRI研究的一个重要阶段，并将其转化为临床。 国际医学磁共振学会（ISMRM）关于WHATEVER：白色的研讨会 物质，分析，翻译，实验验证，评估和复制，将在 纳什维尔，特内塞，2023年9月18日至20日。 WHATEVER研讨会的总体目标是审查最先进的qMRI方法，技术方面和 临床应用，并专注于弥合研究和临床实施之间的差距。可再现 研究促进了临床翻译，并将在整个研讨会上推广，研讨会由 白色物质，来自可再生研究小组的强有力输入。通过联合起来，我们将创造一个 跨学科的环境，其中全会讲座将补充动手教程， 合作项目的想法。 这种面对面的研讨会提供了一个独特的机会，一对一的讨论，非正式的网络， 实习生和既定的研究人员，MD和博士之间的互动。一个专家小组将领导一个 讨论在白色物质中的再现性：剩余的障碍和如何打破它们。科学 程序侧重于qMRI方法，从不同角度研究白色物质：宏观结构（弛豫）， 微观结构（扩散，磁化率）和代谢（CEST，光谱和X-核）。在每届会议上， 物理学家/工程师和医生将提供一个国家的最先进的方法概述，突出有前途的 途径和有趣的临床应用。海报展示是该计划的一个组成部分，将 在Power Pitch演示文稿中进行宣传。 该提案要求提供资金，以（i）支持应邀发言者，免除他们的登记， 和多样化的计划，（ii）通过免除注册和旅行来支持学生和早期研究者 报销费用，以加强会议出席的多样性（包括妇女、代表人数不足的少数群体， 残疾学生和弱势群体），并为少数群体提供 独特的机会，以达到职业发展和合作的国际观众。

PROJECT SUMMARY Diseases of the central nervous system (CNS) are a significant public health and economic problem, affecting nearly one in three Americans at some point in life, with a cost exceeding $500 billion per year. Pathologically, the white matter integrity is compromised in virtually all human neurological diseases/injuries. Quantitative MRI (qMRI) methods hold the promise of improved diagnosis and monitoring of white matter disorders. Despite great advances in the development of sophisticated qMRI methods, their translation into clinic is still in its infancy. This is a critically important time to develop and establish best practices for qMRI in white matter disorders, and it is essential for researchers to come together to share knowledge and map the next phase of qMRI research and its translation into the clinic. The International Society for Magnetic Resonance in Medicine (ISMRM) workshop on WHATEVER: WHite Matter, Analysis, Translation, Experimental Validation, Evaluation & Reproducibility, will be held in Nashville, Tenessee, September 18-20, 2023. The overall aim of the WHATEVER workshop is to review state-of-the-art qMRI methods, technical aspects and clinical applications, and focus on bridging the gap between research and clinical implementation. Reproducible research facilitates clinical translation and will be promoted throughout this workshop, which is organized by the White Matter with strong input from the Reproducible Research Study group. By joining forces, we will create an interdisciplinary environment where plenary lectures will be supplemented by hands-on tutorials and collaborative project ideas. This in-person workshop offers a unique opportunity for one-on-one discussions, informal networking, and interaction between trainees and established researchers, MD and PhDs. A panel of experts will lead a discussion on reproducibility in white matter: remaining barriers and how to break them down. The scientific program focuses on qMRI methods to study white matter from different angles: macrostructure (relaxation), microstructure (diffusion, susceptibility) and metabolism (CEST, spectroscopy and X-nuclei). In each session, a physicist/engineer and physician will provide an overview of state-of-the-art methods, highlight promising avenues and interesting clinical applications. Poster presentations are an integral part of the program and will be advertised in power pitch presentations. This proposal requests funds to (i) support invited speakers by waiving their registrations to enable an excellent and diverse program and (ii) support student and early investigator by waived registration and travel reimbursement to enhance diversity in conference attendance (including women, underrepresented minorities, students with disabilities, and people from disadvantaged backgrounds) and provide minority groups with a unique opportunity to reach an international audience for career development and collaborations.