NY-ESO-1 expression as an inducible chemosensitivity marker

免疫治疗是肺癌治疗的一种新概念。肿瘤睾丸抗原(CTA，如NY-ESO-1)是一种与不良预后相关的免疫原性分子，但我们最近的研究发现，表达NY-ESO-1的肿瘤对化疗更敏感。我们还能够使用去甲基化试剂在正常情况下不表达NY-ESO-1的细胞中诱导NY-ESO-1的表达。我们的目标是确定是否可以通过联合使用这些药物来提高对化疗的反应。

Immunotherapy is a new concept treatment for lung cancer. Cancer testis antigen (CTA, eg NY-ESO-1) is an immunogenic molecule that was related with poor outcomes, but our recent studies have found that tumours that express NY-ESO-1 are more responsive to chemotherapy. We are also able to induce expression of NY-ESO-1 in cells that do not normally express it using demethylating agents. We aim to determine if we can increase the response to chemotherapy by using these drugs in combination.