Mentoring Across Disciplines: Aging and Infectious Diseases with a Focus on Mobility

项目摘要 这个K24中期职业指导奖支持我进一步的职业发展，并为我的职业生涯提供50%的保护时间。 指导和研究。我以病人为导向的研究在艾滋病和老年病之间架起了桥梁。 医学，通过它，我已经制定了一个研究计划，以描述流行病学和潜在的 艾滋病毒和老龄化的机制，并介绍了干预措施，重点是成功的老龄化的人， HIV（和其他传染病）。通过K24奖，我建议把我的研究从板凳上， 通过获得传播/实施方面的培训， 以社区为基础的研究原则（培训目标1）以及健康公平和纳入研究， 指导和领导力（培训目标2）。为这些职业发展提供实践培训 目标，我将专注于改善测量方法的肌肉质量和质量的身体活动 （目标1）。在目标2中，我将通过以下方式努力改进务实和可行的干预方法： 对现有干预措施、关键信息提供者的投入和环境扫描进行系统审查， 专注于可行和可接受的事情。我们将进行系统的回顾， 访谈，并使用混合的方法，将这些发现与数据从父R 01，健康。 最后，我将利用目标1和2中的知识来加强现有的体育活动计划， 传播和执行（目标3）。我将得到具有传播/ 实施和健康公平，除了三个正在进行的导师与跨学科研究 计划，杰出的导师荣誉，并在他们的机构领导地位。最后，我的 该机构为我提供了额外的支持，最关键的是及时保护我免受额外的临床 或行政职责。总之，建议的K24将利用我目前的R 01作为培训 平台的学员，并纳入我的职业发展目标，最终推进科学的 采取干预措施，以保护老年艾滋病毒感染者的身体功能，并支持以患者为导向的研究人员。

PROJECT SUMMARY This K24 Mid-Career Mentoring Award supports my further career development and 50% protected time for mentoring and research. My patient-oriented research has bridged the intersection between HIV and geriatric medicine, through which I have developed a research program to describe the epidemiology and underlying mechanisms of HIV and aging, and introduced interventions focused on the successful aging of people with HIV (and other infectious diseases). Through the K24 award, I propose to take my research from the bench and the bedside into the clinic and community by gaining training in dissemination/implementation and community-based research principles (Training Aim 1) and health equity and inclusion in research, mentorship, and leadership (Training Aim 2). To provide hands-on training for these career development aims, I will focus on improving methods for measurement of muscle mass and quality in physical activity interventions (Aim 1). In Aim 2, I will work to improve methods for pragmatic and feasible interventions through a systematic review of existing interventions, input from key informants, and an environmental scan, with a focus on what is feasible and acceptable. We will conduct a systematic review and individual or group interviews, and used mixed methods to incorporate these findings with data from the parent R01, HEALTH. Lastly, I will use knowledge from Aims 1 and 2 to enhance existing physical activity programs for greater dissemination and implementation (Aim 3). I will be supported by mentors with expertise in dissemination/ implementation and health equity, in addition to three ongoing mentors with cross-disciplinary research programs, outstanding mentorship accolades, and leadership positions within their institutions. Lastly, my institution has provided me with the additional support, most critically in time protected from additional clinical or administrative duties. In summary, the proposed K24 will leverage my current R01 to serve as a training platform for trainees and incorporate my career development objectives, ultimately advancing the science of interventions to preserve physical function in older people with HIV and support patient-oriented researchers.