Imaging Core

马萨诸塞州阿尔茨海默病研究中心：成像核心 马萨诸塞州阿尔茨海默病研究中心（MADRC）的成像核心支持和 进行成像研究，以了解阿尔茨海默病的各种类型的异质性， 阿尔茨海默病相关疾病（AD/ADRD），并加速治疗进展。我们开展 目标1、2和3中的核心职能是通过以下方式整合资源，以增强研究使命 支持和促进MADRC附属的地方和国家研究项目的成像部分， 开发统一的成像协议，有助于了解异质性的新努力， 由于将MADRC研究队列参与者分类为“ATVN”（淀粉样蛋白，tau，血管， 神经变性）生物学研究框架。在目标4、5和6中，我们制定和实施新的 战略和加快进展，以治愈我们的完善和验证的新型PET和 结构和功能MRI方法。这些创新的成像方法在MADRC中进行了评估 研究队列，利用这种深度表型化的参与者队列，涵盖不同的AD/ADRD 诊断，使创新过程具有成本效益（许多参与者已经被成像， 因此，这些措施可以用来促进战略招聘;例如，淀粉样蛋白“阳性”受试者）， 增值（通过比较新的成像措施与我们已经很好地理解的措施）。目标7和8 我们通过为教师、学员、培训人员、数据和软件工具提供专业知识， 和学生在成像研究的最佳实践，并通过提供教育的研究人员，临床医生和 向公众介绍AD和ADRD研究中成像数据的进展、实用性和负责任的解释 最终临床实践。

Massachusetts Alzheimer's Disease Research Center: Imaging Core The Imaging Core of the Massachusetts Alzheimer's Disease Research Center (MADRC) supports and performs imaging research to understand a variety of types of heterogeneity in Alzheimer's disease and Alzheimer's disease related disorders (AD/ADRD) and accelerate progress towards a cure. We carry out core functions in Aims 1, 2, and 3 marshaling resources to enhance the research mission through the support and contributions to imaging components of MADRC-affiliated local and national research projects and the development of uniform imaging protocols that contribute to novel efforts to understand heterogeneity, such as the classification of MADRC Research Cohort participants into the "ATVN" (amyloid, tau, vascular, neurodegeneration) biological research framework. In Aims 4, 5, and 6, we develop and implement new strategies and accelerate progress towards a cure in our refinement and validation of novel PET and structural and functional MRI methods. These innovative imaging methods are evaluated in the MADRC Research Cohort, leveraging this deeply phenotyped cohort of participants spanning diverse AD/ADRD diagnoses to make the process of innovation cost-effective (many participants have already been imaged and so these measures can be used to facilitate strategic recruitment; e.g., of amyloid “positive” subjects) and value-added (by comparing novel imaging measures with those we understand well already). In Aims 7 and 8 we build the future by providing expertise, education, training and data and software tools to faculty, trainees and students for best practices in imaging research and by providing education to researchers, clinicians and the public on the advances, utility and responsible interpretation of imaging data in AD and ADRD research and ultimately clinical practice.