The Sociostructural Implementation Science Coordination Initiative

我们拥有预防艾滋病毒和改善艾滋病毒感染者健康所需的生物医学工具，但 实现终止艾滋病毒流行的目标需要采取社会结构干预措施， 造成不平等的健康决定因素。存在基于证据的社会结构干预措施， 对PrEP，护理相关和病毒抑制结果有直接影响，但它们要少得多 研究比个人层面的干预措施和他们的实施提出了独特的方法， 体制挑战。确定社会结构干预措施如何减少卫生不平等，包括 实施和维持的影响，是一个紧迫的公共卫生研究的优先事项。的 社会结构实施科学协调倡议（SISCI）中心将带来最好的传播 和实施（D&I）科学与同伴R 01合作，以协调数据协调， 促进跨地点学习的机会，协调研究、能力建设和传播 努力我们将提高研究人员和实施者应用D&I模型和方法的能力， 制定、测试和实施社会结构干预措施。SISCI调查员和咨询小组 是国家认可的HIV D&I科学专家，并在协调HIV D&I方面有着良好的记录 项目，并向外地提供工具和培训。SISCI旨在（1）通过以下方式协助伙伴RO 1 关于D&I科学和健康的社会决定因素的合作、知识共享和专家咨询 模型和方法。我们将协调同伴R 01和R 01之间的面对面和虚拟通信 根据集体需求和机会，为项目提供有针对性的方法支持。（二） 整合R 01研究中的实施和有效性数据，以收集跨项目数据并执行 综合分析。使用共享决策，我们将确定公共数据元素（CDE）， 跨项目收集数据，并计划进行综合分析。我们将部署数据协调基础设施， 收集跨项目数据并执行综合分析-只要可能，就获取管理数据， 允许新的可概括的知识超出了个别项目的研究。我们会公布调查结果 利用我们流行的艾滋病毒实施科学网站， 通讯，会议介绍，以及R 01同伴和其他社会结构的特殊期刊问题 项目调查结果。(3)* 通过发展社会结构干预措施，减少艾滋病毒方面的差距 并提供为早期职业调查人员量身定制的D&I科学和社会结构培训， 执行伙伴。我们将通过进行范围审查， 社会结构干预措施的有希望和经证实的执行战略简编。我们将 支持传播R 01伙伴项目中确定的实施战略， 以及传播培训材料和政策简报。

We have the biomedical tools necessary to prevent HIV and improve the health of people living with HIV, yet achievement of the Ending the HIV Epidemic goals requires sociostructural interventions that address social determinants of health that contribute to inequities. Evidence-based sociostructural interventions exist that have a direct impact on PrEP, care-related, and viral suppression outcomes, yet they have been much less studied than individual-level interventions and their implementation poses unique methodological and institutional challenges. Determining how sociostructural interventions can reduce health inequities, including implications for implementation and sustainment, is an urgent public health research priority. The Sociostructural Implementation Science Coordination Initiative (SISCI) hub will bring the best of Dissemination and Implementation (D&I) Science to collaborate with the Companion R01s to coordinate data harmonization, foster opportunities for cross-site learning, and coordinate research, capacity building, and dissemination efforts. We will grow the capacity of both researchers and implementers to apply D&I models and methods for developing, testing, and implementing sociostructural interventions. SISCI investigators and consultative team are nationally recognized experts in HIV D&I science and have a strong record of coordinating HIV D&I projects and providing tools and training to the field. The SISCI aims to (1) Assist the companion RO1s through collaboration, knowledge sharing, and expert consultation on D&I science and social determinants of health models and methods. We will coordinate in person and virtual communications between companion R01s and provide tailored methodological support to the projects based on collective needs and opportunities. (2) Integrate implementation and effectiveness data across R01 studies to collect cross-project data and perform integrated analyses. Using shared decision making, we will identify common data elements (CDEs) for collections across projects and plan for integrated analyses. We will deploy data coordination infrastructure to collect cross-project data and perform integrated analyses—whenever possible obtaining administrative data to allow new generalizable knowledge beyond what individual projects have studied. We will disseminate findings on implementation determinants and strategies using our popular HIV implementation science website and newsletter, conference presentations, and a special journal issue of Companion R01 and other sociostructural project findings. (3) Advance the field of sociostructural interventions to reduce HIV disparities by developing and offering a combined D&I science and sociostructural training tailored to early career investigators and implementation partners. We will further grow the capacity of the field by conducting a scoping review to build a compendium of promising and proven implementation strategies for sociostructural interventions. We will support the dissemination of implementation strategies identified in the Companion R01 projects by creation and dissemination of training materials and policy briefs.