Noncanonical glycogen metabolism and hepatocellular carcinoma

肝细胞癌是世界上最常见和最致命的癌症之一，原因是治疗选择有限，对有效的分子靶点缺乏了解。因此，迫切需要寻找更有效的治疗策略来治疗肝细胞癌。新的证据表明，典型的糖原代谢途径与肝细胞癌的发生和发展有关。然而，非典型的糖原代谢途径在肝细胞癌中的作用仍然是个谜。这项建议的目的是明确靶向非规范的糖原代谢途径如何在不同的小鼠模型中改变肝细胞癌。这些研究的完成将极大地促进我们对肝细胞癌背景下糖原代谢的理解，并可能揭示一种治疗肝细胞癌的新的替代方法，目前对肝细胞癌的治疗选择有限。

Hepatocellular carcinoma is one of the most common and deadliest cancers in the world due to limited treatment options and lack of knowledge of effective molecular targets. Thus, there is an urgent need to identify more effective therapeutic strategies to treat hepatocellular carcinoma. Emerging evidence has shown that canonical routes of glycogen metabolism are linked to hepatocellular carcinoma initiation and progression. However, the role of non-canonical routes of glycogen metabolism in hepatocellular carcinoma remains enigmatic. The objective of this proposal is the define how targeting non-canonical routes of glycogen metabolism modifies hepatocellular carcinoma in various mouse models. Completion of the proposed studies will greatly advance our understanding of glycogen metabolism in the context of hepatocellular carcinoma and potentially reveal a novel alternative approach to treat hepatocellular carcinoma, for which there are currently limited treatment options for.