Molecular Analysis and Statistical Support Facility Core (MASS)

摘要 分子分析和统计支持(MASS)核心支持北卡罗来纳大学中心的主题 环境健康与易感性(CEHS)，翻译环境跨学科研究 北卡罗来纳州改善公共卫生的健康敏感性。群众将提供全面、 用户友好、高效地支持实验室、临床、 和以人口为基础的环境健康调查。群众将提供通道和便利 利用一系列分子核心，并将这种支持与严格和最先进的 生物统计学和生物信息学在研究设计、数据获取和数据分析方面的协助，以支持 环境癌症、心肺疾病和发育领域的翻译研究 疾病(目标1)。质量将开发和实施新的分子和统计方法，以满足 调查人员的分析需求并适应新出现的数据分析战略和独特的数据问题(目标 2)。MASS将提供技术培训，范围从分子方法到统计学、生物信息学和 数据科学，通过研讨会、讲习班和专题讨论会为初级调查人员量身定做CEHS的需求 研究人员(目标3)。我们与全校的基因组学、暴露科学、数据科学和 计算医学，以扩大CEHS调查人员和初级调查人员的影响力和专业知识。 最后，MASS次核心与综合健康科学设施核心(IHSFC)合作运作 支持现有研究、新的试点项目、社区参与和赠款申请(目标4)。主修 在上一个赠款周期内的方案努力和成就包括：更新基础设施和 仪器，使CEHS调查人员能够获得最先进的分析和分子技术； 新方法开发奖励计划，以支持开发创新的新曝光科学和 CEHS调查人员的分子方法；CEHS的新型最先进的数据分析管道 会员。在分子和定量方法开发方面具有专业知识的教员可作为 试点项目和外部赠款的合作者。我们的大众设施核心提供可扩展、高质量、完整 服务核心设施，以满足我们会员从成立到 实施。

ABSTRACT The Molecular Analysis and Statistical Support (MASS) core supports the theme of the UNC Center for Environmental Health and Susceptibility (CEHS), translating interdisciplinary research on environmental health susceptibility to improve public health in North Carolina. The MASS will provide comprehensive, user-friendly, and efficient support for data acquisition, analysis, and interpretation needs of laboratory, clinical, and population-based investigations in environmental health. The MASS will provide access and facilitate utilization of a range of molecular cores and will integrate this support with rigorous and state-of-the-art biostatistics and bioinformatics assistance in study design, data acquisition, and data analysis to support translational research in the areas of Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease (Aim 1). The MASS will develop and implement new molecular and statistical methods to meet investigators' analytic needs and to adapt to emerging data analysis strategies and unique data problems (Aim 2). The MASS will provide technical training, ranging from molecular methods to statistical, bioinformatics, and data science, for junior investigators through seminars, workshops, and symposia tailored to the needs of CEHS researchers (Aim 3). We collaborate with campus-wide efforts in genomics, exposure science, data science and computational medicine to expand the influence and expertise of CEHS investigators and junior investigators. Finally, the MASS subcores function collaboratively with the Integrated Health Sciences Facility Core (IHSFC) to support existing research, novel pilot projects, community engagement, and grant applications (Aim 4). Major program efforts and accomplishments during the past grant cycle include: updated infrastructure and instrumentation to enable CEHS investigators to access state-of-the-art analytical and molecular technologies; a new Method Development Award Program to support developing innovative new exposure science and molecular methods for CEHS investigators; and novel state-of-the-art data analysis pipelines for CEHS members. Faculty with expertise in molecular and quantitative methods development are available and serve as collaborators on pilot projects and external grants. Our MASS facility core provides a scalable, high quality, full service core facility to address data acquisition and analytic needs of our membership, from inception to implementation.