剖腹产新生儿的阴道微生物群播种和健康结果：一项随机对照试验-猫眼课题宝

剖腹产新生儿的阴道微生物群播种和健康结果：一项随机对照试验

批准号：

10927996

负责人：

Suchitra Hourigan

金额：

$167.3万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10927996

关键词：

2 year old 3 year old Adverse event Animal Model Birth Body mass index COVID-19 Cesarean section Child Health Clinical Clinical Research Clinical Trials Data Data Collection Development Disease Electronic Health Record Engraftment Enrollment Exposure to Feces Health Health protection Immune Immune System Diseases Infant Inflammatory Intervention Life Link Mediating Metabolic Metabolic Diseases Methods Microbe Mothers Newborn Infant Obesity Operative Surgical Procedures Oral cavity Outcome Outcome Measure Persons Pilot Projects Procedures Randomized Randomized, Controlled Trials Regulation Research Personnel Safety Site Skin Structure Surveys Swab Testing Vagina Visit arm beneficial microorganism experimental arm follow-up gut microbiota health of the mother high risk immune health insight maternal microbiome microbiome microbiome analysis neonate normal microbiota obesity risk offspring phase 1 study phase 2 study primary outcome restoration sample collection secondary outcome skin microbiota treatment arm vaginal microbiome vaginal microbiota

项目摘要

项目成果

Suchitra Hourigan的其他基金

相似基金

相关文献

中文摘要

翻译

于二零二三财政年度，临床试验因新型冠状病毒疫情暂停两年后继续招募。许多母亲已被招募并随机化，婴儿被随访至3岁，具有连续数据和样本收集点。已经分析了治疗组之间的初始早期生命微生物组数据，并显示治疗组之间的微生物组结构和组成存在差异，阴道接种导致母体微生物组在多个婴儿身体部位植入。阴道接种动物模型已经开始，以获得进一步的机制见解。

英文摘要

During the Fiscal Year 2023, the clinical trial continued enrollment after a 2 year pause due to Covid-19. Many mothers have been enrolled and randomized, with infants being followed up to 3 years of age with serial data and sample collection points. Initial early life microbiome data between treatment arms has been analyzed and shows a difference in microbiome structure and composition between treatment arms and that vaginal seeding causes engraftment of the maternal microbiome in multiple infant body sites. Animal models of vaginal seeding to gain further mechanistic insight have commenced.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文