The complosome in meningeal health and disease

在感染期间和在多发性硬化症等神经炎性疾病期间，细胞内和/或细胞自主补体在脑膜免疫细胞中的作用完全未被探索。因此，这是我们刚刚开始的一个全新的研究领域。我们现在已经产生了在特定脑细胞中特定缺失选定补体基因的独特小鼠品系，目前正在评估这些品系在多发性硬化症小鼠模型中的作用。我们特别针对C5系统，因为我们已经产生了一个C5报告小鼠系。未来的实验还将与C5靶向多肽的体内应用等相结合。

The role of intracellular and/or cell-autonomous complement in immune cells in the meninges during infection and during neuro-inflammatory disease such as multiple sclerosis is completely unexplored. Thus, this is an entirely new research area which we have just started. We have now generated unique mouse strains with specific deletion of selected complement genes in specific brain cells and are currently assessing these in mouse models of MS. We are targeting specifically the C5 system because we have generated a floxed C5 reporter mouse line. Experiments will also be combined in the future with the in vivo application of C5 targeting peptides, etc.