BIOINFORMATICS SUPPORT FOR DNTP & DIR

生物信息学支持合同为Omics技术提供生物信息学支持。需要支持生物信息学分析的项目包括1)支持循环中无细胞DNA(CcfDNA)的毒理基因组分析；2)通过提供10个品系的小鼠的树状图和SNP分析来支持小鼠衰老研究；3)支持对体外细胞转化模型中DNA甲基化变化的表观基因组分析；4)分析HepaRG的3D球体。与Tempo-Seq数据的差异基因表达与折叠变化和p值；5)支持分析微阵列胎盘和肝脏的毒性基因组数据；6)支持AFFF(水性成膜泡沫)分析，用于比较分析体外暴露在HTT检测中的毒性。

The Bioinformatics support contract provides bioinformatics support for Omics technologies. Examples of projects needing support for bioinformatic analysis include toxicogenomic analysis for 1) support for circulating cell free DNA (ccfDNA); 2) support for Mouse Aging study by providing dendogram and SNP analysis for 10 strains of mice; 3) support epigenomic analysis of DNA methylation changes in an in vitro model of cellular transformation; 4) analysis of 3D spheroids of HepaRG. Differential gene expression from TempO-Seq data performed with fold changes and pvalues; 5) support provided for analysis of microarray toxicogenomic data for placenta and liver; 6) support for analysis of AFFF (aqueous film-forming foams) for comparative analysis of toxicity after in vitro exposures in HTT assays.