CEREBELLAR NUCLEI IN EYE MOVEMENT CONTROL AND ADAPTATION

流畅的追逐和扫视的眼球运动需要非常准确地 提供视觉目标的清晰视网膜图像。小脑病变 严重损害眼球运动的时刻对时刻的准确性和 当大脑或外周受损时适应眼球运动的能力 使它们变得不准确。尽管小脑显然是 眼球运动的准确性和适应性，其具体作用是 不清楚。拟议的研究将提供重要的新信息 关于小脑在平稳追踪和眼球跳动中的作用 通过研究小脑核团中最强的两个区域 与它们的控制有关的是尾状顶核(CFN)和 腹外侧错位核(VPIN)。 我们有三个目标。首先，我们将描述CFN在 追逐。我们将描述CFN神经元在不同的 追逃条件和追逃后我们将暂时测量 用GABA激动剂Muscimol灭活GFN神经元。这些结果 将告诉我们CFN活动是否可以支持追捕行动 以及这项活动实际上是如何影响追求的。第二，我们 将调查VPIN在追逐和眼跳运动中的作用。我们 将表征VPIN神经元在这些运动中的反应 描述用麝香酚使VPIN失活如何影响追捕和 扫视。初步结果显示，VPIN中的神经元对 在眼跳过程中与CFN神经元不同，这表明它们 执行不同的功能。我们的数据将使我们能够直接比较 这两个区域的神经元理解为什么大脑的两个独立部分 在相同的运动中，小脑是活跃的。第三，我们将确定 如果CFN或VPIN是适应扫视增益所必需的。我们 将测量其中一个失活前后的适应率 有麝香酚的区域。如果这损害了适应，我们将从 关键区域神经元(S)在适应过程中如何 响应属性会随着增益的变化而改变。先前的工作表明，一些 部分小脑核团是眼跳适应所必需的，但 不确定关键区域。GFN和VPIN是最有可能的区域 因为它们是已知的唯一与眼跳相关的核团区域。 通过描述CFN和VPIN在追逐、扫视和 眼跳适应这项工作将帮助我们了解小脑 在总体上对运动有贡献。

Smooth pursuit and saccadic eye movements need to be extremely accurate to provide clear retinal images of visual targets. Lesions of the cerebellum severely impair both the moment-to-moment accuracy of eye movements and the ability to adapt eye movements when damage to the brain or periphery makes them inaCCurate. Though the cerebellum is clearly indispensable to the accuracy and adaptation of eye movements, its specific role is unclear. The proposed research will provide significant new information about the role of cerebellum in smooth pursuit and saccadic eye movements by studying the two regions in the cerebellar nuclei most strongly implicated in their control, the caudal fastigial nucleus (CFN) and the ventrolateral interpositus nucleus (VPIN). We have three goals. First, we will characterize the CFN's role in pursuit. We will describe the responses of CFN neurons during a variety of pursuit conditions and we will measure pursuit after temporarily inactivating GFN neurons with the GABA agonist muscimol. These results will tell us if CFN activity could support pursuit initiation and maintenance and how this activity, in fact, affects pursuit. Second, we will investigate the VPIN's role in pursuit and saccadic eye movements. We will characterize the responses of VPIN neurons during these movements and describe how inactivating the VPIN with muscimol affects pursuit and saccades. Preliminary results show that neurons in the VPIN respond differently during saccades than do CFN neurons indicating that they perform a different function. Our data will allow us to directly compare neurons in these two regions to understand why two separate parts of the cerebellum are active during the same movements. ThIrd, we will determine if either the CFN or the VPIN is necessary for adapting saccade gain. We will measure adaptation rate before and after we inactivate one of these areas with muscimol. If this impairs adaptation we will record from neurons in the critical area(s) during adaptation to see how their response properties alter as gain changes. Previous work shows that some part of the cerebellar nuclei is necessary for saccade adaptation but does not identify the critical area. GFN and VPIN are the most likely areas because they are the only known saccade-related regions of the nuclei. By describing the role of CFN and the VPIN in pursuit, saccades, and saccade adaptation this work will help us understand what the cerebellum contributes to movements in general.