Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload

为了确定感染，细菌与宿主竞争铁，而铁是供应稀缺的。为了获取铁，细菌会产生一种叫做铁载体的化合物，它能强烈地结合铁。铁-铁载体复合体对每个细菌都是独一无二的，由细菌细胞表面的特定受体识别并进口使用。在这个项目中，我们使用改良的铁载体作为细菌特异性药物设计的平台，目的是生产新的抗生素。

In order to establish an infection, bacteria compete with the host for iron, which is in scarce supply. To access iron, bacteria produce compounds called siderophores which bind iron strongly. The iron-siderophore complex, which is unique to each bacterium, is recognised by specific receptors at the bacterial cell-surface and imported for use. In this project, we are using modified siderophores as platforms for bacteria-specific drug design with the aim of producing new antibiotics.