Age-dependent regulation of type 2 immunity by dermal innate lymphoid cells

2型免疫反应对抵御蠕虫感染至关重要，但也会引起过敏反应。关于2型免疫是如何调控的，人们知之甚少。这项申请的目的是确定一种新发现的皮肤免疫细胞群-真皮2型固有淋巴样细胞-在皮肤蠕虫感染和过敏中的功能。我们预计，我们的研究将有助于制定预防或治疗皮肤过敏和寄生虫感染的策略。

Type 2 immune responses are critical for the defense against worm infections, but can also cause allergic reactions. How type 2 immunity is regulated is poorly understood. The aim of this application is to define the function of a newly discovered skin immune cell population, dermal type 2 innate lymphoid cell, in cutaneous worm infections and allergies. We anticipate that our studies will aid in the development of strategies to prevent or treat skin allergies and parasitic infections.