INTERCONCEPTIONAL ANTIBIOTICS TO PREVENT PRETERM BIRTH

描述（改编自研究者摘要）：具体 本申请的目的是：1）确定 最近在16至23周之间有过自发性流产，或 自然分娩和胎龄24 - 29周分娩， 更可能有慢性子宫内膜微生物定植与U。 溶脲菌、支原体、需氧菌或厌氧菌，或组织学 在解释间隔期间子宫内膜炎症与 近期自然分娩和足月分娩的非妊娠女性;以及 2)进行一项前瞻性随机安慰剂对照试验， 在妊娠期使用抗生素治疗的女性 既往自然流产。 除了确认这是否 治疗根除了微生物定植或炎症的证据， 预防复发性早产，多项次要分析还将 与复发性早产、特定生物体、 子宫内膜组织学模式，子宫内膜取样时间， 治疗

DESCRIPTION (Adapted from the Investigator's Abstract): The specific objectives of this application are to 1) determine if non-pregnant women who have had a recent spontaneous pregnancy loss between 16 and 23 weeks, or spontaneous labor and delivery between 24 and 29 weeks gestational age, are more likely to have chronic endometrial microbial colonization with U. urealyticum, mycoplasma, aerobic or anaerobic bacteria, or histologic endometrial inflammation during the interpregnancy interval compared to non-pregnant women with recent spontaneous labor and delivery at term; and 2) perform a prospective, randomized placebo-controlled trial of antimicrobial therapy during the interpregnancy interval in women with a previous spontaneous pregnancy loss. In addition to confirming if this therapy eradicates evidence of microbial colonization or inflammation, and prevents recurrent preterm deliveries, multiple secondary analyses will also be performed relating to recurrent preterm birth, to specific organisms, patterns of endometrial histology, and timing of endometrial sampling and treatment.