Function of RecQ helicases in genome stability

DNA损伤在生命过程中积累，被认为是导致衰老和基因组不稳定的原因。因此，确定那些维持基因组稳定的蛋白质和途径对于防止衰老和年龄相关的退化至关重要。该项目旨在了解人类RecQ蛋白在DNA修复和基因组稳定性中扮演的角色。 RecQ蛋白在多种DNA代谢途径中发挥重要作用，包括DNA双链断裂修复(DSBR)，包括同源重组(HR)、非同源末端连接(NHEJ)和复制。五个人类RecQ解旋酶中的三个，WRN，BLM和RECQL4，与单基因疾病有关。了解这些蛋白质发挥作用的生化过程以及它们在DNA修复过程中共同或独特的作用仍然是本研究的重点。

DNA damage accumulates during life and is thought to contribute to aging and genomic instability. Therefore, defining those proteins and pathways that maintain genomic stability is critical in preventing aging and age-related degeneration. This project aims to understand what roles human RecQ proteins play in DNA repair and genome stability. RecQ proteins play fundamental roles in several DNA metabolic pathways including DNA double-strand break repair (DSBR), including homologous recombination (HR), non-homologous end joining (NHEJ), and replication. Three of the five human RecQ helicases, WRN, BLM, and RECQL4, are associated with monogenic diseases. Understanding the biochemical processes that these protein function in and their shared or unique roles in DNA repair processes continues to be a focus of this research.