CORE

核心将为每个项目提供必要的重要资源 数据收集、统计分析和项目间协调。Dr。 丹尼斯·斯宾塞将负责选择合适的患者 这项研究，提供组织，安排每周会议，以 维护项目间的完整性；他将帮助开发假设 将临床癫痫问题与基础研究联系起来；他将 协调成像数据，以便精确的神经解剖学 关系是可以维持的，并对整体负责 计划协调。计算机化的定量成像对于 患者选择标准和术中成像是必要的 为每个项目提供重要的细胞架构关联。这个 必须将假定的病理基础与正常的核磁共振进行比较 特别是考虑到这是一次量化考试。新的基金正在 在此重新提交的标准MRI体积研究中要求 提供这一关键的比较。格雷戈里·麦卡锡博士将监督 这方面的影像研究助理。Jung Kim博士证明了 通过提供定性的神经病理评估提供中心资源 并负责海马神经元和神经胶质细胞的定量 细胞计数是所有进一步的形态测量、生理和 生化评估。一个病人数据库已经 已建立，但将提供此计划的统计管理 耶鲁大学生物统计系。

The core will provide important resources necessary for each project's data-gathering, statistical analysis and interproject coordination. Dr. Dennis Spencer will be responsible for selecting patients appropriate for this study, providing the tissue, arranging weekly conferences to maintain interproject integrity; he will help develop hypotheses that connect clinical epilepsy issues with the basic research; he will coordinate the imaging data such that precise neuroanatomical relationships can be maintained, and is responsible for the overall program coordination. Computerized quantitative imaging is critical for patient selection criteria, and intraoperative imaging is necessary to provide important cytoarchitectonic correlation for each project. The presumptive pathological substrate must be compared to normal MRIs particularly since this is a quantitative examination. New funds are requested in this resubmission for a normative MRI volumetric study to provide this critical comparison. Dr. Gregory McCarthy will supervise the imaging research assistant in this regard. Dr. Jung Kim proves a central resource by providing qualitative neuropathological assessment and is responsible for the quantitative hippocampal neuronal, and glial cell counts which underlie all further morphometric, physiological and biochemical assessment. A patient data base has already been established, but statistical management for this program will be provided by Yale's Department of Biostatistics.