FMRI STUDIES OF EMOTION AND COGNITION

描述(改编自摘要)：应聘者申请ISA是为了 开发一种新的研究方法--功能磁共振成像的专业知识。如果没有ISA， 正在进行的临床管理责任将禁止这一职业 发展。候选人过去20年的研究目标 是双重的。首先，他试图确定和评估以下方面 人脑功能涉及多个细胞的综合作用 功能系统通常分布在几个大脑区域。对这件事 他开发并应用了双耳听力和视觉半场 单半球刺激技术，并研究了双任务交互作用 以及情绪或生理状态变化的影响。第二，他有 特别是将这些技术应用于重大精神病的研究 精神分裂症。在那里，目标一直是阐明病理生理学 过程，并有助于发展基于生理的 病因学。功能磁共振成像是一种特别适合于这些目标的新技术。 它产生具有优越的解剖学和时态的个体主题数据 分辨率，并且可以用多种不同的 任务和/或处于多个临床或实验状态。两位物理学家 在全球开发功能磁共振成像的努力中发挥了主导作用的人正在 耶鲁大学的教员。应聘者与以下人员建立了富有成效的合作关系 他们都是神经解剖学方面的杰出科学家， 神经放射学和统计学。ISA将使他能够获得知识 有必要批判性地应用并帮助进一步发展这一新方法 与这个跨学科团队合作。候选人提出了 通过正规的课程学习和每周的学习获得必要的知识 FMRI技术教程、每周教程和一台交互式计算机 神经解剖学基础课程，以及在此过程中的教学互动 合作调查。这项拟议的研究使用功能磁共振成像来识别 人类听觉工作记忆的额叶和颞叶成分 系统，评估这些区域和该系统在患者中的功能 最终，比较情绪对精神分裂症的影响 此系统在患者和健康对照中。

DESCRIPTION (Adapted from abstract): The candidate seeks an ISA in order to develop expertise in a new research method, functional MRI. Without an ISA, ongoing clinical-administrative responsibilities would prohibit this career development. The aims of the candidate's research over the past 20 years have been twofold. First, he has sought to identify and assess aspects of human brain functions that involve the integrated action of many cells in functional systems often distributed through several brain regions. To this end he has developed and applied dichotic listening and visual half-field single hemisphere stimulation techniques, and studied dual task interactions and effects of emotion or changes in physiological state. Second, he has applied these techniques to the study of major psychosis especially schizophrenia. There the goals have been to elucidate pathophysiological processes and contribute to the development of a physiologically based nosology. fMRI is a new technique particularly well-suited for these goals. It yields individual subject data with superior anatomic and temporal resolution, and can evaluate the same individual with multiple variations of task and/or in multiple clinical or experimental states. Two physicists who have played leading roles in the worldwide effort to develop fMRI are on the faculty at Yale. The candidate has developed productive collaborations with both, and with outstanding scientists on their faculty in neuroanatomy, neuroradiology and statistics. An ISA would enable him to gain knowledge necessary to critically apply and help develop further this new methodology in collaboration with this interdisciplinary team. The candidate proposes to gain the requisite knowledge through formal course work and weekly tutorial in fMRI technology, weekly tutorial and an interactive computer based course in neuroanatomy, and didactic interactions during the course of collaborative investigation. The proposed research uses fMRI to identify frontal and temporal lobe components of the human auditory working memory system, evaluate the function of these regions and this system in patients with schizophrenia, and eventually, to compare the effects of emotion on this system in patients and healthy controls.