FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER

此应用程序是为临床医生科学家发展奖 （SDAC），以促进主要研究者在人类方面的研究培训 遗传学及其在严重慢性 儿童和青少年的精神病理学。 要求提供资金， 自由时间追求教学指导和合作研究， 这方面 导师是迈克尔·博恩克博士，副 密歇根大学生物统计学教授。 SDAC活动的科学重点将是强迫症 疾病（0 CD）。CD是一种常见的精神综合征， 在童年，持续到成年，并在家庭中聚集。 它 在其临床表现上相对一致， 寿命 最近的家庭研究表明，0 CD的一种形式与 抽动秽语综合征的遗传学特征 家庭研究使用 目前的诊断程序和分析方法是必要的， 研究0 CD的可能表达和传播方式 在家庭中。 家庭病例对照研究的总体目的描述 本申请的目的是系统地评估和比较 儿童、青少年和 成人先证者0 CD。 假设（1）早发性OCD是 男性患病率高于女性，（2）0 CD的患病率高于女性， 早发型0 CD先证者的亲属中的 晚发型0 CD先证者的亲属，（3）0 CD的遗传是 受单一主要位点的影响，（4）慢性抽动障碍更多 在男性0 CD先证者中常见;（5）慢性抽动的患病率 女性0 CD先证者的亲属中， 男性0 CD先证者的亲属。 将检查数据是否存在其他 结果，包括与匹配的正常对照组及其 亲戚 总之，这项研究将促进我们对 0 CD的病因学，并将提供一个媒介的科学发展 首席研究员的名字

This application is for a Scientist Development Award for Clinicians (SDAC) to further the principal investigator's research training in human genetics and its application to the study of severe, chronic psychopathology in children and adolescents. Funding is requested to free time to pursue didactic instruction and collaborative research in this area. The preceptor will be Michael Boehnke, Ph.D., Associate Professor of Biostatistics at the University of Michigan. The scientific focus for SDAC activities will be obsessive-compulsive disorder (0CD). 0CD is a common psychiatric syndrome that often begins in childhood, persists into adulthood, and aggregates in families. It is relatively consistent in its clinical presentation across the lifespan. Recent family studies indicate that a form of 0CD is related genetically to Gilles de la Tourette syndrome. Family studies using current diagnostic procedures and analytic methods are necessary for investigating the possible modes of expression and transmission of 0CD in families. The general aim of the family case-control study described in this application is to systematically assess and compare the clinical characteristics and family psychiatric history of child, adolescent, and adult probands with 0CD. It is hypothesized that (1) early-onset 0CD is more frequent in males than in females, (2) the prevalence of 0CD is higher in the relatives of probands with early-onset 0CD than in the relatives of probands with late-onset 0CD, (3) the inheritance of 0CD is influenced by a single major locus, (4) chronic tic disorders are more frequent in male 0CD probands, and (5) the prevalence of chronic tic disorders is higher in the relatives of female 0CD probands than in the relatives of male 0CD probands. The data will be inspected for other findings, including comparisons with matched normal controls and their relatives. In summary, this study will advance our knowledge of the etiology of 0CD, and will provide a medium for the scientific development of the principal investigator.