NEUROBIOLOGY OF OPIOID DEPENDENCE

这个应用程序是研究兴奋性氨基酸输入和钙- 与阿片类药物戒断时神经递质的释放有关 拟议 研究计划将检查：1）自发阿片类药物戒断， 临床阿片解毒研究，和2）纳洛酮沉淀 阿片类药物戒断在一个重复的挑战范例。 兴奋性氨基酸 酸对阿片类药物戒断的贡献将首先研究， 美沙芬，一种广泛使用的非阿片类镇咳药， 兴奋性氨基酸神经传递的临床前研究， 显示了治疗阿片类药物戒断的初步疗效。 根据预- 临床和试点人体研究，拟议的研究将确定 中枢作用钙剂尼莫地平的抗戒断作用 通道阻断器。

This application is to study excitatory amino acid inputs and calcium- linked neurotransmitter release during opiate withdrawal. The proposed program of research will examine: 1) spontaneous opiate withdrawal in clinical opiate detoxification studies, and 2) naloxone-precipitated opiate withdrawal in a repeated challenge paradigm. The excitatory amino acid contribution to opiate withdrawal will be studied initially with dextromethorphan, a widely used non-opioid antitussive which inhibits excitatory amino acid neurotransmission in pre-clinical studies, and has shown pilot efficacy for treatment of opiate withdrawal. Based on pre- clinical and pilot human studies, the proposed research will determine the anti-withdrawal efficacy of nimodipine, a centrally-acting calcium channel blocker.