MECHANISTIC STUDY OF PT IV ANTICANCER COMPLEXES

说明：许多铂化合物具有抗肿瘤活性。 实体瘤。即使是最广泛使用的抗肿瘤铂药物顺铂， 表现出许多不良副作用。某些PtIV复合药物展示 毒性更小，作为前体药物发挥作用，转化为更具活性的药物 细胞内的PtII种。本申请涉及 PtIV转化为ptII物种的还原化学。这是假设的 PtIV复合体的轴向配体可能在 控制这种转化的还原化学，从而产生 PtII的各种类似物，表现出广泛的细胞毒性。崔博士 在此应用程序中建议通过以下方式测试此假设的有效性 用高分辨电子能谱研究PtIV化合物的动力学和反应化学 高效液相色谱、UV/VIS和195铂-核磁共振光谱分析。

DESCRIPTION: Many Pt compounds show antitumor properties against various solid tumors. Even the most widely used antitumor Pt drug, cisplatin, exhibits many adverse side effects. Certain PtIV - complex drugs exhibit less toxicity and function as prodrugs that are converted into more reactive PtII species intracellularly. The present application deals with the reduction chemistry of ptIV conversion to PtII species. It is hypothesized that the axial ligands of the PtIV complexes may play an important role in controlling the reduction chemistry of this conversion, thereby generating various analogs of PtII that exhibit a wide range of cytotoxicity. Dr. Choi proposes in this application to test the validity of this hypothesis by studying the kinetics and reaction chemistry of PtIV compounds by high performance liquid chromatography, UV/vis and 195Pt-NMR spectroscopy.