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Novel roles for neural crest cells in cardiac morphogenesis

Novel roles for neural crest cells in cardiac morphogenesis
神经嵴细胞在心脏形态发生中的新作用
批准号:
nhmrc : 1144004
负责人:
Dr Quenten Schwarz
金额:
$37.45万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-01-01 至 2021-12-31

项目摘要

项目成果

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中文摘要
翻译
心脏流出道的异常形成会导致常见的畸形,影响超过1%的新生儿。利用新的小鼠模型,这项资助旨在确定神经脊细胞控制心脏流出道形成的分子机制。这项研究产生的新信息将确定可能用于预测性测试和再生疗法的新靶点。
英文摘要
Abnormal formation of the cardiac outflow tract leads to common malformations affecting over 1% of all births. Taking advantage of novel mouse models this grant aims to identify the molecular mechanisms by which neural crest cells control formation of the cardiac outflow tract. New information generated from this study stands to identify new targets which may be used for predictive testing and regenerative therapies.
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会议论文
Defining the role of IGF-1 as a novel angiocrine factor in the development and treament of common craniofacial disorders
  • 批准号:
    nhmrc : 1144008
  • 项目类别:
    Project Grants
  • 资助金额:
    $38.8万
  • 财政年份:
    2018
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  • 依托单位:
Investigation of the role of PI3-kinase in the regulation of angiogenesis
  • 批准号:
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  • 项目类别:
    Project Grants
  • 资助金额:
    $57.63万
  • 财政年份:
    2016
  • 负责人:
    Dr Quenten Schwarz
  • 依托单位:
Defining the role of VEGF and vascular formation in craniofacial development
  • 批准号:
    nhmrc : 1067848
  • 项目类别:
    Project Grants
  • 资助金额:
    $42.44万
  • 财政年份:
    2014
  • 负责人:
    Dr Quenten Schwarz
  • 依托单位:
Defining the role of Nedd4 in neural crest cell development
  • 批准号:
    nhmrc : 1051066
  • 项目类别:
    Project Grants
  • 资助金额:
    $36.11万
  • 财政年份:
    2013
  • 负责人:
    Dr Quenten Schwarz
  • 依托单位:
海外基金