SECOND CONFERENCE ON DNA TOPOISOMERASES IN CANCER

我们建议组织第二届DNA拓扑异构酶大会 癌症化疗“，1988年10月17日至19日，纽约 大学医学中心。筹备和组织 会议将包括： 1.以邮寄方式传播有关会议的信息 以及通过在科学期刊上刊登广告或公告。 2.实际会议的安排，会议将作为 为期三天的会议，包括四次全会幻灯片 演讲，并有两个海报会议。每次幻灯片会议 将包括受邀的演讲者，其中大多数是 现场，以及选定提供的论文的演讲者。那里 全体会议有四个专题：(一)人类遗传研究 拓扑异构酶；(Ii)拓扑异构酶I导向的药物； 拓扑异构酶II的抑制剂及其作用机制； (4)与拓扑异构酶相关的耐药性。 3.以全文形式出版会议讲稿。一个 将尝试将会议记录作为单独的一期出版 美国国家情报局的专著。 会议的目标有三个：(一)扩大和 DNA拓扑异构酶的生物学研究进展 化疗药物的抑制机制；(Ii)一次 再一次，将癌症研究人员和临床医生聚集在一起 对话题感兴趣，加速信息传递 从基础科学进入药物开发和临床研究； 以及(3)评估目前的进展和讨论未来的方向 在这个领域。将作出特别努力，将科学家包括在内 不仅来自美国和加拿大，也来自国外。

We propose to organize the `Second Conference on DNA Topoisomerases in Cancer Chemotherapy', in October 17-19, 1988, at the New York University Medical Center. The preparation and organization of the Conference will include: 1. Dissemination of information regarding the conference by mail and by advertisement or announcements in scientific journals. 2. Organization of the actual conference which will be held as a three day meeting with four plenary sessions of slide presentations, and with two poster sessions. Each slide session will include invited speakers, most of them leading experts in the field, as well as presenters of selected proffered papers. There are four topics of plenary sessions: (i) Genetic studies of topoisomerases; (ii) Topoisomerase I-directed drugs; (iii) Inhibitors of topoisomerase II and mechanism of their action; and (iv) Topoisomerase-related drug resistance. 3. Publication of conference lectures as full-size articles. An attempt will be made to publish the proceedings as a separate issue of the NCI Monographs. The goals of the conference are three-fold: (i) To broaden and update information concerning biology of DNA topoisomerases and the mechanism of inhibition by chemotherapeutic agents; (ii) Once again, to bring together cancer researchers and clinicians interested in the topic, accelerate the transfer of information from basic science into the drug development and clinical studies; and (iii) To assess present advances and discuss future directions in this field. A special effort will be made to include scientists not only from the United States and Canada, but also from abroad.