CEREBRAL BLOOD FLOW AND METABOLISM IN MENINGITIS

这项研究计划的目标是研究 细菌性脑膜炎的病理生理和代谢后果 在兔子模型中。主要研究领域是 脑血流量与脑血管自动调节、改变 在大脑的代谢过程中，包括葡萄糖的利用 和乳酸生产，以及与发展有关的因素 有颅内压升高。这些异常现象在 患有细菌性脑膜炎的儿童和成人，很可能 导致常见的神经系统后遗症。 我们将尝试定义它们之间的相互关系 变量及其致病因素。角色 微生物因素和宿主炎症反应将 被评估为评估他们对 伴随脑膜炎而来的精神错乱。将开展研究 在这个实验室里，建立了脑膜炎的模型 一种可以同时重复测量的兔子 一系列生理和生化参数。 我们将对脑血流量进行连续测定， 脑氧和葡萄糖代谢率，脑乳酸 产酸、颅内压和脑脊液 白血球计数、细菌滴度和 葡萄糖和乳酸。选择性颅脑手术 压力、乳酸、细菌滴度和浓度 细菌细胞壁成分和白细胞反应 使我们能够评估它们对 脑血流灌注。 拟议的研究将定义病理生理学的演变。 细菌性脑膜炎的生化变化及病因分析 导致这些变化的因素，并建立 循环和代谢改变之间的相互关系。

The objectives of this research proposal are to examine the pathophysiologic and metabolic consequences of bacterial meningitis in a rabbit model. Principal areas of study are changes in cerebral blood flow and cerebrovascular autoregulation, alteration in metabolic processes in the brain including glucose utilization and lactic acid production, and the factors relating to development of intracranial hypertension. These abnormalities are seen in children and adults with bacterial meningitis and are likely to contribute to neurologic sequelae which commonly occur. We will attempt to define the interrelationships between these variables and the etiologic factors responsible for them. The role of microbiologic factors and the host inflammatory response will be valuated to assess their independent contribution to the derangements which accompany meningitis. Studies will be developed in this laboratory, of a well established model of meningitis the rabbit with which we can make simultaneous and repeated measurement of a number of physiologic and biochemical parameters. We will perform sequential determinations of cerebral blood flow, cerebral metabolic rate for oxygen and glucose, cerebral lactic acid production, intracranial pressure, and cerebrospinal fluid white blood cell counts, bacterial titers and concentration of glucose and lactate. Selective manipulation of intracranial pressure, lactic acid, bacterial titers and concentration of bacterial cell wall components, and white blood cell response will allow us to assess their relative contribution to alterations in cerebral perfusion. The proposed studies will define the evolution of pathophysiologic and biochemical changes in bacterial meningitis and the etiologic factors responsible for these changes, and establish the interrelationships between circulatory and metabolic alterations.