Pilot Grant Program

项目摘要/摘要 微生物致病和宿主中心研究人员的主要研究支持手段 第三阶段的炎症反应(CMPHIR)将是NIGMS资助的试点赠款计划(PGP)， 补充机构资金(每年100,000美元)，以支持董事创新基金。 重点将是确定具有与科学主题一致的研究兴趣的新调查人员 CMPHIR。将为明显符合CMPHIR科学范围的项目提供支持，包括 特别强调研究可能与现有CMPHIR有协同作用的调查人员 调查人员，从而最大限度地扩大发展协同合作的机会。我们还将 继续我们在第二阶段开始的努力，支持解决传染病问题的项目 最全面的时尚，并且可以与内置的实验基础相结合 第一阶段和第二阶段。在具体感兴趣的领域中包括调查改进诊断的项目 方法，开发更有效的抗菌药物，将批准的药物重新用于 传染病应用、疫苗开发、抗感染生物材料的开发 特性，并了解宿主共病对感染易感性和反应的影响 到治疗性干预。此外，PGP和董事创新基金将用于支持高度 UAMS其他研究单位战略外部招聘，招聘具有研究能力的新调查人员 与CMPHIR的科学主题相一致的兴趣。这将使CMPHIR继续增长和 随着我们进入第三阶段和第三阶段，我们将成熟为自我维持的生物医学研究卓越中心 更远一点。

PROJECT SUMMARY/ABSTRACT A primary means of research support for investigators in the Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR) in Phase III will be the NIGMS-funded Pilot Grant Program (PGP), supplemented with institutional funds ($100,000 per year for each year) to support a Director's Innovation Fund. The focus will be on identifying new investigators with research interests consistent with the scientific theme of the CMPHIR. Support will be provided for projects that clearly fit within the scientific scope of the CMPHIR, with a particular emphasis on investigators whose research is potentially synergistic with existing CMPHIR investigators, thereby maximizing opportunities for the development of synergistic collaborations. We will also continue the efforts we started in Phase II to support projects that address issues in infectious disease in the most comprehensive fashion possible and one that can be integrated with the experimental foundation built in Phases I and II. Included among specific areas of interest are projects investigating improved diagnostic methods, the development of more effective antimicrobial drugs, the potential to repurpose approved drugs for infectious disease applications, vaccine development, the development of biomaterials with anti-infective properties, and understanding the impact of host comorbidities on the susceptibility to infection and the response to therapeutic intervention. In addition, the PGP and Director's Innovation Fund will be used in support of highly strategic external recruitment by other research units at UAMS recruiting new investigators with research interests consistent with the scientific theme of the CMPHIR. This will allow the CMPHIR to continue to grow and mature into a self-sustaining Center of Biomedical Research Excellence as we move forward into Phase III and beyond.