Diseases of Public Health Importance Training Grant

项目摘要 培训计划的具体目标是培养研究生和博士后研究员在 将现代生物技术的原理和理论应用于具体的疾病问题。病理学 该计划提供了分子方法和全球健康之间的接口。这次训练使命是 在我们的研究生课程，其中包括病理生物学核心课程的课程要求的支持 强调公共和全球健康原则，分子/细胞生物学，疾病的科学方法 相关问题，以及流行病学和免疫学课程。多种研究合作融合了我们的 以实验室为基础的培训与其他公共卫生部门提供了独特的机会， 对具有全球卫生意义的疾病进行多学科研究。我们的培训计划的显著特点 包括重点：1）与全球健康有关的病原体; 2）慢性疾病的传染性因素; 3） 影响孕产妇和儿童健康的疾病; 4）全球健康问题; 5）保护性和功能性免疫 6）疫苗开发战略; 6）干预和药物发现的新方法;以及7） 生物标志物的鉴定。病理生物学培训学院由53名导师组成，他们共同拥有 在这些核心和独特的重点领域的专业知识。病理学博士前培训计划 1990年获得华盛顿大学研究生院批准，获得跨学科项目 2006年获得地位，2017年正式转入全球卫生部。此举进一步 通过扩大学生对全球健康原则的学习，加强了我们的培训计划， 促进与国际学者的互动。自1990年以来，我们已经毕业了122个博士学位。自1990年以来，我们 学院培养了660多名博士后研究员。拟议的培训计划将培养3名博士预科生和3名 每年培养博士后。多样化的研究和课堂环境的结合提供了一个 采取强有力的综合办法，使受训人员能够做好准备，最有效地应对 全球健康的疾病。

Project Summary The specific objectives of the training program are to train graduate students and postdoctoral fellows in the application of principles and theories of modern biotechnology to specific disease problems. The Pathobiology program provides an interface between molecular approaches and global health. This training mission is supported by the course requirements in our graduate program, which include core courses in Pathobiology emphasizing principles of public and global heath, molecular/cell biology, scientific approaches to disease related issues, and courses in epidemiology and immunology. The multiple research collaborations melding our laboratory-based training with other Public Health Disciplines offer unique opportunities to conduct multidisciplinary studies on diseases of global health significance. Distinguishing features our training program include a focus on: 1) Pathogens relevant to global health; 2) Infectious contributors to chronic diseases; 3) Diseases affecting maternal and child health; 4) Global health issues; 5) Protective and functional immune responses; 6) Vaccine development strategies; 6) Novel methods for intervention and drug discovery; and 7) identification of biomarkers. The Pathobiology training faculty consists of 53 mentors, who collectively have expertise within each of these core and unique focus areas. The predoctoral training program in Pathobiology was approved by the University of Washington Graduate School in 1990, received Interdisciplinary Program Status in 2006, and formally moved into the Department of Global Health in 2017. This move has further enhanced our training program through broadening our students’ learning of global health principles and fostering interactions with international scholars. We have graduated 122 PhDs since 1990. Since 1990, our faculty have trained over 660 postdoctoral fellows. The proposed training program will train 3 predoctoral and 3 postdoctoral trainees per year. The combination of diverse research and classroom environments provide a strong integrated approach to enable trainees to prepare for and deal most effectively with the impact of disease on Global Health.