Effect Of Intra-aortic Balloon Pump In A Canine Model Of Septic Shock

在美国，感染性休克是内科和外科重症监护病房中最常见的死亡原因。30%死于败血症的患者心输出量低。本研究的目的是探讨主动脉内球囊反搏（IABC）在治疗感染性休克中的作用。IABC降低心脏上的后负荷，辅助心脏收缩，同时增强其冠状动脉血流量，增强舒张。 我们有一个ACUC批准的方案，在一个充分表征的低心输出量脓毒症动物模型中进行IABC的对照、随机生存研究。 IABC的总体作用是通过增加冠脉灌注增加心肌氧供应，并通过减少收缩期后负荷减少心肌氧需求。我们发现，主动脉内球囊反搏导致生存时间延长和血管加压药依赖性降低。这些数据已被分析，手稿已被接受出版于2008年由重症监护医学。

Septic shock is the most common cause of death in medical and surgical intensive care units in the United States. Thirty percent of patients who die from sepsis are noted to have low cardiac output. The purpose of this study is to examine the role of intra-aortic balloon pump counterpulsation (IABC) in the treatment of septic shock. IABC reduces the afterload on the heart, assisted systole, while enhancing its coronary blood flow, diastolic augmentation. We have an ACUC approved protocol to perform a controlled, randomized survival study of IABC in a well characterized low cardiac output animal model of sepsis. The overall effect of the IABC is to increase myocardial oxygen supply by increasing coronary perfusion during diastole, and decrease myocardial oxygen demand by decreasing afterload during systole. We found that intra-aortic balloon pumping resulted in a increase in survival time and a decrease in vasopressor dependence. This data has been analyzed and a manuscript has been accepted for publication in 2008 by Critical Care Medicine.