Studies on CDNF: a new class of neurotrophic proteins

研究CDNF蛋白在大鼠单侧最大病变PD - 6-OHDA模型中的作用。CDNF在6-OHDA颅内注射至上升DA束之前和两周后给予。我们研究了CDNF蛋白对亲本注射MPTP诱导的小鼠双侧PD模型的影响。我们研究了CDNF蛋白在MitoPark小鼠模型中的作用。我们正在开发小鼠CDNF零突变，并将研究中脑DA系统的发育。我们将生成AAV-CDNF，并在6-OHDA大鼠模型以及MPTP和MitoPark小鼠模型中测试其效果。这种载体的体内试验，如果成功产生，将在未来的研究中进行。

We study effects of CDNF protein in the rat unilateral maximal lesion PD 6-OHDA model. CDNF is administered prior to, and two weeks after, intracranial injection of 6-OHDA into the ascending DA bundle.We study effects of CDNF protein in the mouse bilateral PD model induced by parental injection of MPTP. We study effects of CDNF protein in the MitoPark mouse model. We are developing a mouse CDNF null mutation and will study development of the midbrain DA system. We will generate AAV-CDNF and in order to test effects in the 6-OHDA rat model and in the MPTP and MitoPark mouse models. In vivo tests of such a vector, if successfully generated, will be carried out in future research.