Interactions of diet, macronutrient metabolism, and body weight change in humans

这项临床研究首次使用我们实验室开发的人体新陈代谢计算模型来设计，该模型模拟了大量营养素新陈代谢和身体成分随着饮食和体力活动的变化而变化的情况(见报告1 Z01 DK013036)。根据我们目前对人体新陈代谢的了解，该模型允许我们预测各种饮食中大量营养素新陈代谢和身体成分的可能变化，以及在实验测量精度的情况下检测这些变化所需的时间长度。我们进行了几项模拟临床研究，并选择了最有可能以合理的费用产生成功结果且对研究对象造成的不便最小的方案设计。计算模型还将用于分析这项研究的数据，并将其整合到我们对人体大量营养素代谢和身体成分调节的整体理解的更广泛背景下。

For the first time, this clinical study was designed using a computational model of human metabolism developed by our laboratory that simulates adaptations of macronutrient metabolism and body composition in response to changes of diet and physical activity (see report 1 Z01 DK013036). Based on our current knowledge of human metabolism, the model allowed us to predict the likely changes of macronutrient metabolism and body composition for various diets, as well as the length of time required to detect those changes given the precision of the experimental measurements. We conducted several simulated clinical studies and selected the protocol design that had the best chance of producing successful results at a reasonable expense and with minimum inconvenience to the study subjects. The computational model will also be used to analyze the data from this study and integrate it within a broader context of our overall understanding of human macronutrient metabolism and regulation of body composition.