Problem Solving in Transplant Patients and Caregivers

本研究的目的是测试潜在的应用解决问题的教育干预的患者和家庭照顾者经历异基因造血干细胞移植（HSCT）。增加解决问题的能力可以减少痛苦，并可能改善症状和健康相关的QOL。准备好的家庭护理干预，也被称为科普，已证明对癌症患者及其家庭有益，但其目前的应用存在局限性。只有一项研究报告了这种干预在急性护理环境中的应用，没有对接受HSCT的患者进行研究。 一旦受试者同意在NIH临床中心参加同种异体HSCT，则将其纳入本方案。研究于2008年1月完成入组。筛选了34对可能参与的二人组，10对二人组（患者和护理人员，N = 20）合格并同意入组。24对由于非英语口语/阅读和不一致的护理人员在场而被杀死。目前正在分析数据。 本研究的结果将指导未来的研究，研究与接受同种异体HSCT的二人组中的常规护理组教育相比，与解决问题教育干预相关的预测因素和结果。

This study is designed to test the potential application of a problem-solving education intervention for patients and family caregivers experiencing allogeneic hematopoietic stem cell transplantation (HSCT). An increase in problem-solving has been shown to decrease distress and may improve symptom distress and health related QOL. The Prepared Family Caregiving intervention, also known as COPE, has demonstrated benefit in cancer patients and their families, however there are limitations to its current application. Only one study has reported the application of this intervention in the acute care setting and no study has been done with patients undergoing HSCT. Subjects were accrued to this protocol once they have agreed to participate in an allogeneic HSCT at the Clinical Center, NIH. The study completed enrollment 1/2008. 34 dyads were screened for potential participation, 10 dyads (patient and caregiver, N = 20) were eligible and agreed to be enrolled. 24 dyads were in-eligibile due to non-English speaking/reading and inconsistent caregiver presence. Data are currently being analyzed. The results to this study will guide future research examining predictors and outcomes associated with problem solving education intervention as compared to usual care group education in dyads receiving allogeneic HSCT.