CMPB Central Pathology Support

在过去的一年里，以协作和支持为导向的工作对心血管疾病（动脉粥样硬化）、炎症性呼吸系统疾病、肥胖和II型糖尿病、炎症和免疫介导的肾脏疾病、基因表达和基因调控、轴向骨骼发育和饮食限制的跨代影响等一系列疾病和疾病过程的研究和理解产生了影响。为了使临床实验室保持最新状态，采用了新的方法和仪器。例如，增加了一个Aperio扫描范围，用于组织切片的数字成像和成像分析。CellCut激光显微解剖范围（分子机器和工业）已纳入靶向和捕获特定细胞或细胞群。此外，还获得了Meso Scale Discovery公司的SECTOR Imager 2400，用于检测多种血清生物标志物，包括但不限于肌钙蛋白T和I、脂肪酸结合蛋白3、炎症因子（如白介素、TNFa、INFg）、生长因子（如VEGF）、激素（如胰岛素、瘦素、雌酮、黄体酮、睾酮）。

Collaborative and support oriented work has over the past year had an impact in the study, and on the understanding, of a spectrum of diseases and disease processes such as cardiovascular disease (atherosclerosis), inflammatory respiratory disease, obesity and type II diabetes, inflammatory and immune-mediated renal disease, gene expression and gene regulation, axial skeletal development and transgenerational effects of diet restriction. To keep the clinical laboratory up-to-date, new methods and instruments have been obtained. For example, An Aperio Scan Scope has been added for digital imaging and imaging analysis of tissue sections. A CellCut laser microdissection scope (Molecular Machines and Industries) has been incorporated for the targeting and capture of specific cells or cell populations. Additionally, a SECTOR Imager 2400 by Meso Scale Discovery was obtained for the performance of a variety of serum biomarkers, in single- or multi-plex fashion, including, but not limited to, troponin T and I, fatty acid binding protein 3, inflammatory cytokines (e.g., interlukins, TNFa, INFg), growth factors (e.g., VEGF), hormones (e.g., insulin, leptin, etradiol, progeterone, testosterone).