Translational Research at The University of Chicago (UL1)

芝加哥大学CTSA计划的最终目标是培养科学家和医疗保健人员 大学的提供者、我们的合作机构和我们的社区来确定分子 任何个体患者的疾病或疾病易感性的基础；开发、测试、实施和 使我们社区的居民可以随时获得针对这些个人的个性化治疗 基础；并以严格、有效、高效、道德和尊重我们的 社区的需求和价值观。在与阿贡国家实验室的强大联盟中，伊利诺伊州研究所 技术和两个大型医疗机构，我们将采取三个大胆的新步骤，将 转变我们机构和社区的临床和转化性研究：1)创建 转化医学研究所，一个新的大学范围的结构，收集、整合和传播 促进和支持多学科所需的智力、组织和资源基础设施 翻译研究协作；2)与新的UC城市健康中心的协同研究互动 通过与社区利益攸关方合作，旨在改善社区卫生保健的倡议 机会和质量，在整个社区建立健康素养和信任，增强翻译能力 由社区提供信息并响应社区需求的研究计划，从而减少健康 差异；以及3)建立一个新的临床和翻译科学学术委员会和 多个新颖的培训计划，以鼓励和发展临床和转化性研究的职业生涯， 面向高中生、大学教师和整个翻译研究 频谱。我们的CTSA专职调查员联盟将采用系统医学方法来 利用他们在社会科学、基因医学和综合疗法方面的特殊专业知识。一起， 这个团队和这些变革性的创新将使芝加哥大学CTSA能够为下一个 一代临床和转化型研究人员，以实现我们广泛可用、有效和 个性化治疗在社区实践中得到日常应用，从而降低健康 不同的成人和儿科人群之间的差异。

The ultimate goals of the University of Chicago CTSA program are to train scientists and health care providers at the University, our partner institutions, and our Community to determine the molecular underpinnings of disease or disease predisposition in any individual patient; to develop, test, implement, and make readily available to residents in our Community personalized therapies directed toward those individual underpinnings; and to do this in a way that is rigorous, valid, efficient, ethical, and respectful of our Community's needs and values. In a robust alliance with Argonne National Laboratory, the Illinois Institute of Technology, and two large healthcare organizations, we will undertake three bold new steps that will transform clinical and translational research at our institutions and in our Community: 1) Creation of an Institute for Translational Medicine, a new University-wide structure to collect, integrate, and disseminate the intellectual, organizational, and resource infrastructure needed to promote and support multidisciplinary translational research collaborations; 2) Synergistic research interaction with a new UC Urban Health Initiative which, through partnership with Community stakeholders, aims to improve Community health care access and quality, to build health literacy and trust throughout the Community, to enhance a translational research program informed by and responsive to the needs of the Community, and so to reduce health disparities; and 3) Establishment of a new academic Committee on Clinical and Translational Science and of multiple novel training programs to encourage and develop careers in clinical and translational research, intended for high school students through university faculty and across the entire translational research spectrum. Our consortium of dedicated CTSA investigators will employ a systems medicine approach to leverage their particular expertise in social science, genetic medicine, and integrative therapeutics. Together, this team and these transforming innovations will allow the University of Chicago CTSA to prepare the next generation of clinical and translational researchers to realize our vision of widely available, effective, and personalized therapies that find everyday application in Community practice and thereby reduce health disparities in diverse adult and pediatric populations.