IMAGING

结构成像提供了可视化与认知衰退相关联的解剖学变化的手段(例如， 项目3“健康老龄化和早期DAT的注意特征”)和候选替代标记物 用于检测早期DAT与其他生物标志物的结合(例如，项目2 脑脊液中AD的生物标志物“。核心E：成像的目标是收集、存储和传播成像 用于使用本方案项目调查的数据，也是为了促进 支持未来成像项目的基础设施。实现以下具体目标：1.结构性 将与CORE密切协调，收集痴呆症和非痴呆症参与者的成像数据 B：临床，纵向间隔两年。结构成像电池将包括(I)多个 采集高对比度MP-RAGE图像，(Ii)用于评估白质的3D T2图像。这些 图像将用于测量皮质和皮质下萎缩以及评估白质。 (3)弥散张量成像评估脑白质微结构完整性；(4)T2-SWI 图像。此外，还将收集痴呆症和非痴呆症参与者的功能成像数据。 在休息期间，功能成像数据将是粗体图像，以评估功能连接性。2.研究 神经放射学评估将由委员会认证的神经放射科医生对所有结构图像数据进行。 布景。3.结构数据集将与核心C：生物统计一起存档，并通过 一个基于网络的界面，让调查人员进行研究项目。4.量化结构评估将 用于将成像数据与特定于项目的数据相关联，包括：(I)自动估计整个- 脑萎缩，(Ii)对海马、内嗅觉、额叶和其他皮质体积的手动估计，(Iii) 从Freesurfer软件获得的皮质和皮质下体积的自动估计(Fischl等人， 2002年；Fischl等人，2004；Desikan等人，2006)，以及(Iv)白质的自动评估 高强度。还将提供定量功能评估，以将成像数据与 特定于项目的数据，并将包括对种子区域之间的功能连接性的估计，例如 海马体和楔前叶。5.与核心C：生物统计和核心A密切合作： 管理，数据将被管理，以将核心的功能与计划的科学目标相结合 项目。

Structural imaging provides a means to visualize change in anatomy associated with cognitive decline (e.g., Project 3 "Attention Profiles in Healthy Aging and Early Stage DAT") and also candidate surrogate markers for detection of early-stage DAT in combination with other biomarkers (e.g., Project 2 "Antecedent biomarkers of AD in CSF"). The goal of the Core E: Imaging is to collect, store, and disseminate imaging data for the use of the present program project investigations and also to facilitate the development of infrastructure to support future imaging projects. The following Specific Aims will be pursued: 1. Structural imaging data on demented and nondemented participants will be collected, in close coordination with Core B: Clinical, at two-year longitudinal intervals. The structural imaging battery will include (i) multiple acquisitions of high contrast MP-RAGE images, (ii)3D T2 images for assessment of white matter. These images will be used for measurement of cortical and subcortical atrophy and assessment of white matter integrity, (iii)diffusion tensor imaging to assess white matter microstructural integrity, and (iv)T2-SWI images. In addition, functional imaging data on demented and nondemented participants will be collected. The functional imaging data will be BOLD images during rest to assess functional connectivity. 2. Research neuroradiological assessment will be made by board-certified neuroradiologists on all structural image data sets. 3. Structural data sets will be archived in conjunction with Core C: Biostatistics and made available via a web-based interface to investigators to pursue research projects. 4. Quantitative structural assessment will be provided for correlating imaging data with project-specific data including (i) automated estimates of whole- brain atrophy, (ii) manual estimates of hippocampal, entorhinal, frontal, and other cortical volumes, (iii) automated estimates of cortical and subcortical volumes derived from Freesurfer software (Fischl et al., 2002; Fischl et al., 2004; Desikan et al., 2006), and (iv) automated assessment of white matter hyperintensities. Quantitative functional assessment will also be provided for correlating imaging data with project-specific data and will include estimates of the functional connectivity between seed regions such as the hippocampus and the precuneus. 5. Working closely with Core C: Biostatistics and Core A: Administration, data will be managed to integrate the Core's function with the scientific goals of the program project.