Administrative Core

麻省理工学院的会计系统每个项目和 核心人员负责核对报表，将估计费用与实际支出进行比较， 确保保存适当的文件。一个技术报告、手稿和重印本的储存库， 出版物已经建立，并将由弗朗西斯女士在项目主任办公室保存。 核心3的一项重要职能是与科学合作者协调活动。这些包括 安德森医院的伊丽莎白·格里姆、国家癌症研究所的柯蒂斯·哈里斯、 俄勒冈州健康科学中心，蒙大拿大学的肯特萨格登和卫理公会的梅兰妮伊里格 医院研究所。与格林博士的合作涉及黑色素瘤孢子，哈里斯博士与 病变的结肠组织，劳埃德博士与细胞和小鼠是修复缺陷的过氧化基地，博士。 Sugden用金属氧化剂处理过的细胞，Ihrig博士用动物研究的统计分析。在 除了正式的合作之外，我们还经常收到有关分析方法和要求的询问。 服务这包括提供生物样品中的硝酸盐/亚硝酸盐分析，将细胞暴露于NO， 质谱分析法来 PHS 398/2590（2004年9月修订，2006年4月重新印发） 主要研究者/项目负责人：Tannenbaum，Steven R. 数据共享计划 与NIH政策一致，本项目的研究人员致力于共享以下研究数据： 完成了国家卫生研究院资助的项目。最终研究数据的共享促进了发现过程， 因此，具有重大的科学和公共利益。遵守NIH共享政策的具体方法 研究数据概述如下。 数据将尽可能列入出版物和相关补充材料。在这 在此背景下，该计划对同行评审的硝酸盐/亚硝酸盐和一氧化氮做出了重大贡献 研究文献，在最近发表的研究文章，书籍章节或书籍超过105篇 更新期。 该计划将产生各种形式的数据，包括微阵列数据，1-D和2-D凝胶，Western blot和免疫组织化学。 印迹、组织学报告、色谱和光谱数据文件，以及数据库搜索结果，例如， 通过串联质谱实验鉴定蛋白质。因此，这将需要各种 存储和传输的格式。例如，凝胶和印迹将被扫描并以JPEG或 TIFF格式。LC/MS/MS实验的结果可以在EXCEL中总结为表格或存储 以电子方式作为原始数据文件。 存档的电子数据，例如，LC色谱图和质谱图可根据要求在CD上提供 或DVD或通过互联网/FTP。与出版物相关的数据摘要将以PDF文件的形式发布在MIT 一氧化氮网站（http：//web.mit.edu/noppg/）。 最后，计划成员不断发展新的合作和伙伴关系，并对请求开放 对于来自其他科学家的数据或合作，在HIPAA规定的范围内，以及对于未发表的 专有数据。 PHS 398/2590（2004年9月修订，2006年4月重新印发）

by the MIT accounting system. Each Project and Core are responsible for reconciling statements to compare estimated costs with actual expenditures and to ensure proper documentation is maintained. A repository of technical reports, manuscripts and reprints of publications has been established and will be maintained in the office of the Program Director by Ms. Francis. An important function for Core 3 is the coordination of activities with scientific collaborators. These include Elizabeth Grimm at M.D.Anderson Hospital, Curtis Harris of the National Cancer Institute, Stephen Lloyd of the Oregon Health Sciences Center, Kent Sugden of the University of Montana, and Melanie Ihrig of the Methodist Hospital Research Institute. The collaboration with Dr. Grimm relates to the melanoma SPORE, Dr. Harris with diseased colonic tissue, Dr. Lloyd with cells and mice that are repair deficient for hyperoxidized bases, Dr. Sugden with cells treated with metal oxidants, and Dr. Ihrig with statistical analysis of the animal studies. In addition to the formal collaborations, we receive frequent inquiries about methods and requests for analytical services. This includes providing nitrate/nitrite analysis in biological samples, exposure of cells to NO,and mass spectrometry. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 350 Continuation Format Page Continuation Page PrincipalInvestigator/Program Director: Tannenbaum, Steven R. Data Sharing Plan Consistent with NIH policies, the investigators in this Program are committed to share research data on completed NIH-funded projects. The sharing of final research data facilitates the discovery process and is, therefore, of great scientific and public benefit. Specific approaches to comply with the NIH Policy on Sharing of Research Data are outlined below. To the extent practical, data will be included in publications and associated supplementary material. In this context, the Program has made significant contributions to the peer-reviewed nitrate/nitrite and nitric oxide research literature, with over 105 research articles, book chapters, or books published during the most recent renewal period. The Program will generate data in a variety of forms, including microarray data, 1-D and 2-D gels, Western blots, histology reports, chromatographic and spectroscopic data files, and results of databases searches, e.g., protein identifications via tandem mass spectrometry experiments. These will therefore require a variety of formats for storing and transmission. Gels and blots, for example, will be scanned and archived in JPEG or TIFF format. Results of LC/MS/MS experiments can be summarized as tables in EXCEL or stored electronically as raw data files. Archived electronic data, e.g., LC chromatograms and mass spectra can be made available on request on CDs or DVDs or by internet/FTP. Data summaries related to publications will be posted as PDF files on the MIT Nitric Oxide website (http://web.mit.edu/noppg/). Finally, Program members continually develop new collaborationsand partnerships, and are open to requests for data or collaboration from other scientists, within the limits established by HIPAA, and for unpublished proprietary data. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 351 Continuation Format Page