Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology

该项目的目的是开发统计方法和范例，以更好地利用从大规模流行病学研究中收集的大量外周血DNA甲基化数据。特别是，我们的重点是开发和优化使用DNA甲基化谱来“标记”环境暴露的统计方法，以便这些信息可以更好地用于研究复杂性状和疾病的遗传和环境基础。

The aim of this project is to develop statistical methods and paradigms to better leverage the considerable amount of peripheral blood DNA methylation data that has been collected from large scale epidemiological studies. In particular, our focus is on developing and optimizing statistical methods of using DNA methylation profiles to “tag” environmental exposures, so that this information can be better utilized to investigate the genetic and environmental basis of complex traits and diseases.