Animal Core

动物中心将继续为每个项目的研究人员提供协助， 涉及动物的研究。核心将提供与所有项目密切相关的专业知识， 有效利用宝贵的资源。核心是私家侦探，伊博士。凯勒在前列腺方面有丰富的经验 癌症异种移植发展和前列腺癌的啮齿动物模型，包括胫骨内和心内 注射模型凯勒博士将监督核心的科学方向。核心的日常活动 将由美国实验动物医学院认证兽医Jill Keller博士监督。 动物核心活动包括： - 为项目制作动物模型。例如， 将由Animal Core对小鼠进行造血管模型。 - 协助动物实验。核心人员将协调、协助或指导 执行标准化程序，如胫骨内和心内注射，麻醉， 等 为动物研究提供成像能力。核心将进行faxitron射线照片，骨 光密度测定法（Dexa或pQCT）和生物发光。 - 根据各种项目的需要，为各种专门的小鼠维持繁殖群。 将根据需要保留特定的遗传修饰小鼠。 - 新型骨转移动物模型的建立。J.凯勒医生将测试异种移植物和细胞 来源于前列腺孢子的细胞系作为骨转移模型的能力。

The Animal Core will continue to provide investigators of each project with assistance in the conduct of research involving animals. The core will provide a focus of expertise that is germane to all projects and also efficiently utilize valuable resources. The core's PI, Dr. E. Keller has extensive experience with prostate cancer xenograft development and rodent models of prostate cancer including intratibial and intracardiac injection models. Dr. Keller will oversee the scientific direction of the core. The core's day-to-day activities will be overseen by Dr. Jill Keller, an American College of Laboratory Animal Medicine certified veterinarian. The Animal Core activities include: - Creating animal models to be used for the projects. For example, implantation of vertebrae of mice to create vossicle models will be performed by the Animal Core. - Assisting with animal experiments. Core personnel will coordinate and assist or instruct in the performance of standardized procedures such as intratibial and intracardiac injection, anesthesia, etc. Providing imaging capability for animal studies. The core will perform faxitron radiographs, bone densitometry (Dexa or pQCT), and bioluminescence. - Maintaining breeding colonies for various specialized mice as required for various projects. Specific genetically-modified mice will be maintained as required. - Development of new animal models of bone metastasis. Dr. J. Keller will test xenografts and cell lines derived from the Prostate SPORE for their ability to serve as models of skeletal metastasis.