The pigmentary system: securing a place in the sun

描述（由申请人提供）：泛美色素细胞研究学会正准备于2009年9月4日至7日在田纳西州孟菲斯举行第15届年会-“色素系统：在阳光下获得一席之地”。在上一次PASPCR 2007年年会上，我们提议吸引对色素沉着疾病感兴趣的基础科学家和临床医生，以便集中精力将现有知识应用于治疗服务不足的患者群体。在皮肤生物学的广阔领域中，色素沉着是一个不断发展的研究领域。因此，本次会议的主题涉及公共卫生利益的独特方面和不同主题，从发育生物学，色素沉着的生物化学，黑色素体和免疫识别，干细胞和恶性转化，到环境对色素沉着的影响，包括太阳辐射的影响，健康差异和色素沉着疾病，皮肤颜色的遗传和社会生物学。讨论的重要议题之一是与太阳辐射的紫外线波长有关的生物危害，导致皮肤致癌。在这种情况下，piglitazone系统作为一个有据可查的保护，防止太阳辐射，以及一个有效的系统，抵消行动的活性氧物种。另一方面，紫外线辐射（UVB）对皮肤产生维生素D3至关重要，维生素D3是体内钙稳态的主要调节剂和具有多效性作用的激素。还有其他系统减轻氧化应激，如黑素能系统。此外，色素系统在皮肤神经内分泌系统内运作，并与免疫系统相互作用。这些研究主题共享感兴趣的领域，使基础研究人员和临床医生与色素沉着的主要或衍生利益，沟通新的和未发表的研究数据和治疗结果。这个机会有助于新想法的出现和富有成效的合作。我们的孟菲斯位置为'09会议将允许容易和相对负担得起的访问会议为所有美国的研究人员和临床医生。卫理公会保健指定最多26 AMA PRA类别1学分的教育活动。本次会议目前申请资金的目的是支持主旨发言人和杰出的年轻研究人员，通过在与会者中出版和分发最终方案和摘要来加强会议的教育和科学方面，通过一个开放访问的网站和教育材料来教育公众，在PASPCR通讯上发表论文，在色素细胞和黑色素瘤研究杂志上发表摘要和程序，促进和加强色素兴趣小组与其他研究小组之间的更多合作，以扩大和进一步整合基础和临床研究。 公共卫生相关性：2009年泛美色素细胞研究协会会议将在田纳西州的孟菲斯举行，会议主题为“色素系统：在阳光下保护一个地方”，以更新研究者对色素系统最新的基础和临床发现。它将为基础研究人员和临床医生提供一个论坛，以满足和分享皮肤和眼睛色素沉着的复杂领域的数据，其在人类健康，太阳辐射的环境影响和种族多样性的更广泛的影响。我们期望在分子、细胞和整个生物体水平上更好地理解这一过程，这可能会导致更有效的治疗色素性疾病，从罕见的遗传异常到自身免疫性疾病和皮肤恶性肿瘤。色素细胞生物学与其他领域，如皮肤病学，基础生物学，神经生物学，内分泌学，免疫学，光生物学，眼科学，病理学，生物化学，化学，物理学和癌症研究的最新进展将被介绍。重要的是，认识到色素沉着也是种族歧视的基础，影响到个人的福祉和整个社会，PASPCR为讨论健康和社会问题开辟了必要的空间。预计将讨论色素细胞研究的新途径，并提出未来的发展方向，使这一领域成为基础科学和生命科学的前沿。由ACCME认证的卫理公会医疗保健公司为医生提供继续医学教育，决定共同赞助这次会议，并指定这次教育活动最多26个AMA PRA第1类学分。

DESCRIPTION (provided by applicant): The PanAmerican Society for Pigment Cell Research is preparing to hold its 15th Annual Meeting - "The Pigmentary System: Securing a Place Under the Sun" in Memphis, TN on September 4-7, 2009. At the last PASPCR 2007 annual meeting, we proposed to attract both basic scientists and clinicians interested in pigmentary disorders in order to concentrate efforts in applying the existing knowledge towards the treatment of underserved patient populations. Within the vast field of cutaneous biology, pigmentation is a growing area of research. The theme of this meeting therefore touches on unique facets and diverse topics of public health interest, ranging from developmental biology, biochemistry of pigmentation, melanosomes and immune recognition, stem cells and malignant transformation, to the environmental effects on pigmentation including the effect of solar radiation, health disparities and pigmentary disorders, inheritance of skin coloration and sociobiology. Among important topics discussed is the biohazard connected with the ultraviolet wavelengths of the solar radiation with resulting cutaneous carcinogenesis. In this context pigmentary system serves as well documented protector against solar radiation as well as an efficient system counteracting the action of reactive oxygem species. On the other hand ultraviolet radiation (UVB) is crucial for cutaneous production of vitamin D3, a major regulator of body calcium homeostasis and hormone with pleiotropic effects. There are also other systems attenuating oxidative stress such as melanoninergic system. Furthermore, pigmentary system is operating within the skin neuroendocrine system and interacts with the immune system. These research topics share areas of interest that allow basic researchers and clinicians with a primary or derivative interest in pigmentation to communicate novel and unpublished research data and treatment outcomes. The opportunity contributes to the emerging of novel ideas and fruitful collaborations. Our Memphis location for the '09 meeting will allow easy and relatively affordable access to the meeting for all US based researchers and clinicians. Methodist Healthcare designates this educational activity for a maximum of 26 AMA PRA Category 1 Credits. The objectives of the current application for funding of this meeting are to support keynote speakers and outstanding young investigators, to enhance the educational and scientific aspect of the meeting by publishing and distributing the final program and abstracts among the participants, to educate the general public with an open access website with educational material, publication of proceeding in the PASPCR Newsletter and publication of the abstracts and programs in the Journal Pigment Cell and Melanoma Research, and to facilitate and strengthen more collaboration between pigment interest groups and other research groups that can broaden and further integrate the basic and clinical research. PUBLIC HEALTH RELEVANCE: NARRATIVE The 2009 meeting of the PanAmerican Society for Pigment Cell Research and suggestively entitled "The Pigmentary System: Securing a Place Under the Sun" will be held in Memphis, TN to update investigators on the most novel basic and clinical findings in the pigmentary system. It will provide a forum for basic researchers and clinicians to meet and share data on the complex field of skin and eye pigmentation with its wider implications in human health, environmental effects of solar radiation and racial diversity. We expect to achieve a better understanding of the process at molecular, cellular and entire organism levels that might lead to more effective treatments for pigmentary disorders ranging from rare genetic abnormalities to autoimmune disorders and skin malignancies. Recent advances in pigment cell biology interfacing with other areas such as dermatology, basic biology, neurobiology, endocrinology, immunology, photobiology, ophthalmology, pathology, biochemistry, chemistry, physics and cancer research will be presented. Importantly, realizing that pigmentation is also the basis for racial discrimination with an impact for the individual well being and for the society as a whole, the PASPCR opens the necessary space for discussion on health and social issues. It is expected that new avenues in pigment cells research will be discussed and future directions proposed to place this field on the forefront of basic and life sciences. Methodist Healthcare accredited by the ACCME to provide continuing medical education for physicians decided to co-sponsor this meeting and designated this educational activity for a maximum of 26 AMA PRA Category 1 Credits.