Symposium on Hereditary Breast & Ovarian Cancers: Risk and Challenges

描述（由申请人提供）：本次遗传性乳腺癌和卵巢癌国际会议是继先前在欧洲和美国分别组织的个别研讨会之后举行的。会议结构包括关于预防和早期诊断乳腺癌和卵巢癌的一般主题的介绍性会议，另外五次全体会议涉及与这些肿瘤的生物学和临床意义有关的各个方面，并以包括圆桌会议的会议结束，该会议将处理这一问题的管理策略。虽然五次全体会议的重点是遗传性癌症（在患有这些癌症的妇女中占少数），但越来越明显的是，从家庭内发生的癌症中吸取的教训也在不同程度上适用于“零星”发生的癌症，即事先不知道遗传性疾病。事实上，这些癌症的预防、诊断和治疗方面的进展与遗传性癌症方面的进展齐头并进：与宿主激素环境有关的癌症易感性、早期检测的磁共振成像、特定遗传异常导致的DNA修复缺陷导致癌症的影响。我们预计，这次会议将汇集来自两大洲的专家，并由该领域感兴趣的年轻工作者参加，将导致讨论与疾病风险有关的一些问题，以及如何在更早（和更有利）的情况下解决这些风险的挑战。 公共卫生相关性：在美国，乳腺癌和卵巢癌每年造成约60，000人死亡。遗传性癌症虽然只占这些发病率的10%，但在确定相关遗传特征和实施预防和监测措施方面起着主导作用。因此，这次会议将是感兴趣的工作人员处理乳腺癌和卵巢癌的各个方面。

DESCRIPTION (provided by applicant): This international meeting on hereditary breast and ovarian cancer follows on the heels of prior individual symposia previously organized separately in Europe and in United States. The meeting structure consists of an introductory session on the general topic of prevention and early diagnosis of breast and ovarian cancer, five additional plenary sessions dealing with various aspects related to the biology of these tumors and to the clinical implications, and ending with a session including a round table that will deal with strategies in management of this problem. Although the focus of the five plenary sessions is on hereditary cancers (making up the minority of women afflicted with these cancers), it has become increasingly obvious that the lessons learned from their occurrence within families are also applicable to a variable extent to those that occur 'sporadically' -that is, without prior knowledge of a hereditary condition. In fact, the progress in prevention, diagnosis and treatment of these cancers has gone hand in hand with what is being learned in hereditary cancer: predisposition to cancer in relation to the host's hormonal environment, magnetic resonance imaging in early detection, implications of DNA- repair defects resulting from specific genetic abnormalities in causing cancer. We anticipate that this meeting, bringing together experts from two continents, and attended by interest young workers in the field will lead to discussion on a number of issues relating to disease-risks, and the challenges on how to address these risks at earlier (and more favorable) circumstances. Public Health Relevance: Cancers of the breast and ovary account for approximately 60,000 deaths annually in the United States. Hereditary cancers, although only accounting for 10% of these occurrences, lead the way in the determination of relevant genetic characteristics and in the implementation of preventive and surveillance measures. Thus this meeting will be of interest to workers dealing with all aspects of breast and ovarian cancers.