FASEB Meeting on Mitosis: Spindle Assembly and Function

描述(申请人提供)：有丝分裂是指在细胞分裂过程中将复制的染色体分配给子细胞，使每个细胞继承一套完整的遗传指令的过程。有丝分裂是细胞和分子生物学的一个基本主题，但研究的主题也包括生物化学、细胞生物学、功能基因组学和生物物理学的学生。此外，由于这一过程中的缺陷可能导致基因组不稳定、出生缺陷和癌症，因此对这一基本过程的研究与人类健康和美国国立卫生研究院的使命有关。因此，我们正在寻求资金，以支付2009年8月30日至9月4日在意大利托斯卡纳卢卡Il Ciocco Resort Lucca举行的FASEB会议的部分费用，会议由美国纽约奥尔巴尼Wadsworth中心的Conly Rieder教授和美国印第安纳大学Bloomington的Claire Walczak教授组织。会议的目的是汇聚来自有丝分裂领域不同次级学科的约175名研究人员，以促进以综合形式交流信息和思想。为此，我们建议举行平台会议：1.中心体和纺锤体极结构：2.动点：3.纺锤体的组装和组织：4.微管动力学、马达和纺锤体功能：5.有丝分裂进程：6.染色体分离和有丝分裂退出：7.有丝分裂作为一个药理靶点。此外，还将举行特别平台会议，表彰该领域的长期贡献者，并由埃里希·尼格博士发表主旨演讲。为了补充平台会议，将在整个会议期间看到两组海报，每天下午留出时间供正式观看和与海报主持人讨论。下午剩下的时间将留作“自由时间”，以促进讨论、非正式科学交流和启动合作。据我们所知，这是唯一一次完全专注于有丝分裂的定期会议。 公共卫生相关性：有丝分裂纺锤体将遗传物质忠实地分离到子细胞，这对有机体的生存至关重要。由于这一过程中的缺陷可能导致基因组不稳定、出生缺陷和癌症，因此对这一基本过程的研究与人类健康和美国国立卫生研究院的使命有关。因此，将研究有丝分裂各个方面的研究人员聚集在一起的计划将加强对这一重要生物学过程的理解。

DESCRIPTION (provided by applicant): Mitosis is the process by which replicated chromosomes are distributed to the daughter cells during cell division so that every cell inherits a complete set of genetic instructions. Mitosis is a fundamental topic in cell and molecular biology, and yet the topic of study also includes students of biochemistry, cell biology, functional genomics, and biophysics. Moreover, since defects in the process can contribute to genomic instability, birth defects, and cancer, the study of this fundamental process is relevant to human health and the mission of the NIH. Accordingly we are seeking funds to partially defray the costs of a FASEB meeting on "Mitosis: Spindle Assembly and Function" to be held August 30 - September 4, 2009 at Il Ciocco Resort Lucca, Tuscany, Italy, organized by Professors Conly Rieder of the Wadsworth Center Albany, New York, USA and Claire Walczak of Indiana University, Bloomington, Indiana, USA. The purpose of the meeting is to bring together approximately 175 researchers from the various sub-disciplines within the field of mitosis in order to stimulate the exchange of information and ideas in an integrated format. To this end we propose to hold platform sessions on: 1. Centrosomes and spindle pole structure: 2. Kinetochores: 3. Spindle assembly and organization: 4. Microtubule dynamics, motors and spindle function: 5. Mitotic Progression: 6. Chromosome segregation and mitotic exit: 7. Mitosis as a pharmacological target. In addition, there will be a special platform session to honor long-standing contributors to the field as well as a keynote address by Dr. Erich Nigg. To complement the platform sessions, two sets of posters will be visible throughout the meeting, with time set aside each afternoon for formal viewing and discussions with the poster presenters. The remainder of the afternoons will be set aside as "free time" to facilitate discussion, informal scientific exchanges, the initiation of collaborations. To our knowledge, this is the only regular meeting that focuses entirely on mitosis. PUBLIC HEALTH RELEVANCE: The faithful segregation of genetic material by the mitotic spindle to daughter cells is essential for the survival of an organism. Because defects in the process can contribute to genomic instability, birth defects, and cancer, the study of this fundamental process is relevant to human health and the mission of the NIH. The plan to bring together researchers who study all aspects of mitosis will therefore enhance the understanding of this important biological process.