7th Pathways, networks and Systems Medicine Conference

描述(由申请人提供)： 请求为第七届路径、网络和系统医学会议提供支持。从系统的角度理解健康和疾病的重要性日益被认为是对传统简化论范式的高度优先补充。特别是，对复杂生物系统中每个组成部分的功能的深刻理解必须与多层次系统分析完全结合起来。这些组分的功能只有在系统性质的背景下才有意义，类似地，只有具有坚实的分子基础的系统才有意义。在每一种情况下，都必须包括作为系统扰动的遗传变异(突变和多态)以及环境因素(例如饮食、药物和微生物)的后果，以便反映人类状况的自然情况。这种组件和系统的互补集成是生物医学研究的主要挑战之一，也是这些会议的重点。 路径、网络和系统医学会议独特地将复杂的多层次生物系统的实验研究与严格的计算、生物信息学、统计和分析方法相结合。重点是哺乳动物系统，以便最大限度地提高与人类疾病的相关性。然而，其他物种的突破性发现也被包括在内，这些发现导致了重要的系统原则、研究策略、分析范式和表型方法。课程主题集中在(1)癌症，(2)新陈代谢和心血管系统，(3)干细胞，发育和再生，以及(4)免疫和炎症。参加人数限制在100人以下，以促进互动。这次会议是一个平衡的组合，既有正式的、有平台的演讲，也有充足的时间进行非正式讨论。鼓励妇女、学生、研究员、来自传统上在科学领域代表性不足的团体的个人和残疾人参加，并在演讲方案中获得优惠的财政支持和安置。希腊提供了一个国际会议的中心地点，而科孚则是一个孤立的地点，鼓励个人在整个会议期间留下来。 历届会议的反馈都很特别--比如，“各方面都是有史以来最好的会议”，“我不希望会议结束，科学实在太棒了”，还有“30-30年来我参加过的最重要的会议”。尽管其他会议聚焦于相关的基因组学、计算和系统问题，但没有一次会议明确关注人类和哺乳动物模型的系统医学，也没有一次会议将计算和实验研究无缝而有效地结合在一起。(摘要结束)

DESCRIPTION (provided by applicant): Support is requested for the 7th Pathways, Networks and Systems Medicine Conference. The importance of understanding health and disease from a systems perspective is increasingly recognized as a high priority complement to the traditional reductionist paradigm. In particular, a deep understanding of the functions of every component in complex biological systems must be fully integrated with multilevel systems analysis. The functions of these components make sense only in the context of systems properties, and similarly systems are meaningful only with a firm molecular foundation. In each case, the consequences of genetic variation (mutations and polymorphisms) as well as environmental factors (e.g. diet, drugs and microbes), which act as systems perturbations, must be included in order to reflect the natural circumstances of the human condition. This complementary integration of components and systems is one of the primary challenges in biomedical research, and it is the focus of these Conferences. The Pathways, Networks and Systems Medicine Conferences uniquely blend experimental studies of complex multilevel biological systems with rigorous computational, bioinformatics, statistical and analytical approaches. Emphasis is on mammalian systems in order to maximize the relevance to human disease. However, breakthrough discoveries in other species are included where they lead to important systems principles, research strategies, analytical paradigms, and phenotyping methods. Session topics focus on (1) cancer, (2) metabolism and cardiovascular systems, (3) stem cells, development and regeneration, and (4) immunity and inflammation. Attendance is limited to less than 100 to promote interactions. The conference is a balanced mix of formal, platform presentations with ample time for informal discussions. Women, students, fellows, individuals from groups who are traditionally under-represented in science, and persons with disabilities are encouraged to attend, and receive preferential financial support and placement in the presentation program. Greece provides a central location for an international conference and Corfu an isolated location that encourages individuals to remain for the entire conference. Feedback from previous conferences has been exceptional, - 'best conference ever in every way', 'I don't want the conference to end, the science is so good', and 'the most important conference I've attended in 30 thirty years' for example. Although other conferences focus on related genomics, computational and systems issues, none focus explicitly on systems medicine in humans and mammalian models, and none integrate computational and experimental studies as seamlessly and effectively. (End of Abstract)