2009 Nucleic Acids Gordon Conference

描述（由申请人提供）：戈登核酸研究会议首次成立于50多年前。从那时起，核酸领域爆发了关于核酸的化学，功能潜力和生物学意义的巨大发现。通过所有这些进展，核酸GRC为专门从事核酸研究的所有不同领域的研究人员提供了一个讨论新想法和互动的重要论坛。特别是，过去的十年已经带来了关于细胞中核酸功能的广度（即所有类别的ncRNA）以及核酸生物合成和加工中的各个步骤在机械上相互交织的程度的重新认识和兴奋。RNAi参与染色质沉默和重塑是将看似不同的核酸研究领域聚集在一起的有用性的一个主要例子。2009年的核酸GRC会议将突出DNA和RNA生物学、生物化学和生物物理学领域的最新进展，以期确定这些领域的新兴概念和技术。具体的讨论主题将包括：基因组完整性，DNA复制，转录和染色质动力学，转录后调节，ncRNA：对DNA和RNA的不同影响，RNA命运决定：稳定性和出口，核糖体生物发生，功能和调节以及RNA催化。将特别鼓励年轻科学家或新从事核酸研究的科学家参加并发表演讲;从提交的摘要中选出的简短演讲的时间安排将被纳入日程。 公共卫生相关性：戈登核酸研究会议于50多年前首次成立。从那时起，核酸领域已经爆发了关于核酸的化学，生物学意义和治疗潜力的巨大发现。例如，几种RNAi疗法正在临床试验中作为黄斑变性和丙型肝炎的治疗方法进行测试。其中一些疗法是基于在Nucleic Acids GRC上提出和讨论的发现。2009年的Nucleic Acids GRC将继续提供一个重要的论坛，供专门从事核酸研究的所有不同领域的研究人员讨论新的想法和互动，以期认识到治疗人类疾病的潜在新想法。

DESCRIPTION (provided by applicant): The Gordon Research Conference on Nucleic Acids was first established more than 50 years ago. Since that time the field of nucleic acids has exploded with tremendous discoveries regarding the chemistry, functional potential and biologic significance of nucleic acids. Through all of these advances the Nucleic Acids GRC has provided a critical forum for discussion of new ideas and interaction between investigators specializing in all the diverse areas of nucleic acids research. In particular, the past decade has brought renewed recognition and excitement regarding the breadth of nucleic acid functions in cells (i.e. all classes of ncRNAs) and the extent to which various steps in nucleic acids biosynthesis and processing are mechanistically intertwined. The involvement of RNAi in chromatin silencing and remodeling is a prime example for the usefulness of bringing seemingly diverse areas of nucleic acid researchers together. The 2009 meeting of the Nucleic Acids GRC will highlight recent advances in these areas of DNA and RNA biology, biochemistry and biophysics with a view toward identifying emerging concepts and technologies in these fields. Specific topics of discussion will include: Genome integrity, DNA replication, Transcription and chromatin dynamics, Post-transcriptional regulation, ncRNAs: Diverse effects on DNA and RNA, RNA fate decisions: stability and export, Ribosome biogenesis, function and regulation and RNA catalysis. Young scientists, or those newly engaged in nucleic acids research, will be particularly encouraged to attend and present; with time built into the schedule for short talks selected from submitted abstracts. Public Health Relevance: The Gordon Research Conference on Nucleic Acids was first established more than 50 years ago. Since that time the field of nucleic acids has exploded with tremendous discoveries regarding the chemistry, biologic significance and therapeutic potential of nucleic acids. For example, several RNAi therapeutics are being tested in clinical trials as treatments for macular degeneration and for hepatitis C. Some of these therapeutics are based on discoveries that were presented and discussed at the Nucleic Acids GRC. The Nucleic Acids GRC in 2009 will continue to provide a critical forum for discussion of new ideas and interaction between investigators specializing in all the diverse areas of nucleic acids research with an eye to recognizing potential new ideas for the treatment of human disease.