Workshop on the Role of HLA-B27 in Spondyloarthritis

描述（由申请人提供）：本提案是一项资金申请，用于举办为期3天的国际研讨会，研究人员的研究旨在了解HLA-B27与脊柱关节炎密切相关的基础。这种非常强的遗传关联已经被发现了35年，但其机制仍然未知，许多不同的假设仍然存在。拟议讲习班的具体目标是：[1]通过使用背景总结和简要概述介绍，澄清关于HLA-B27的知识现状和解释其在脊柱关节炎中作用的当前假设[2]通过广泛的指导讨论，确定知识差距，完善和扩展现有假设，并制定该领域应该朝着的研究目标[3]通过持续的讨论，建立合作和/或联盟，并确定能够推动实现这些目标的筹资机会[4]为了吸引和保持年轻的研究人员在这一领域的兴趣，总的目标是加快一天，当一个详细的分子理解HLA-B27在脊柱关节炎中的作用。实现这一目标有望改善这一重要而常见的风湿性疾病的预防和治疗手段。

DESCRIPTION (provided by applicant): This proposal is a request for funds to hold a 3-day international workshop of investigators whose research is aimed at understanding the basis for the strong association of HLA-B27 with spondyloarthritis. This very strong genetic association has been known for 35 years, but the mechanism remains unknown and many different hypotheses continue to be entertained. The specific objectives of the proposed workshop are: [1] Through the use of background summaries and brief overview presentations, to clarify the current state of knowledge regarding HLA-B27 and the current hypotheses to explain its role in spondyloarthritis [2] Through extensive guided discussions, to identify gaps in knowledge, refine and extend existing hypotheses, and formulate research goals toward which the field should move [3] Through continued discussions, to establish collaborations and/or consortia, and to identify funding opportunities that would advance pursuit of these goals [4] To attract and maintain the interest of young investigators in this field The overall goal is to hasten the day when a detailed molecular understanding of the role of HLA- B27 in spondyloarthritis. Accomplishing this goal is expected to lead to improved means of prevention and treatment of this important and common group of rheumatic diseases.