International Pediatric Nephrology Association (IPNA) Eighth Symposium on Growth

描述(由申请人提供)：国际儿科肾病协会(IPNA)第八届慢性肾脏疾病儿童生长与营养研讨会将讨论儿科肾病学家和内分泌学家在护理患有生长障碍的婴儿、儿童和青少年时面临的主要挑战，这些婴儿、儿童和青少年面临严重共病和死亡的风险。研讨会将以以往会议的成功为基础，提供：1)深入讨论和更新突出的热点问题，2)关于正在进行的和创新的研究路线的信息，3)临床和基础研究人员之间互动的适当框架，以及4)促进新的研究小组和年轻研究人员的加入。生长迟缓是儿童慢性肾脏病的常见结果，导致患者无法达到与其遗传潜力一致的最终成年身高。尽管我们对生长异常的细胞和分子病因以及旨在预防或纠正生长缺陷的明确治疗方法的理解取得了重大进展，但北美儿童肾脏试验和合作研究数据库中37%的CKD儿童有法定生长障碍。此外，来自美国肾脏数据系统数据库的数据表明，重度至中度生长障碍患者的住院率和死亡风险都有所增加。生长发育障碍在慢性肾脏病儿童心血管危险因素发病率和患病率较高中的作用尚不清楚。考虑到这些问题，以及目前NIDDK--支持儿童慢性肾脏疾病队列研究的结果，在IPNA的指导下，一个国际科学组织委员会召集了一批在生长及其在健康和疾病方面的监管方面具有专业知识的杰出研究人员，以便在西班牙奥尔维耶多召开为期三天的互动科学会议，旨在促进该领域的新研究，并促进新的调查人员和受训人员的发展。竞争性旅行赠款将为他们提供出席和参加会议的机会，他们的研究将通过同行审查的海报会议征求高级调查人员的批判性反馈。一个网站将传播会议信息。

DESCRIPTION (provided by applicant): The International Pediatric Nephrology Association's (IPNA) Eighth Symposium on Growth and Nutrition in Children with Chronic Renal Disease will address the major challenges facing pediatric nephrologists and endocrinologists in the care of infants, children and adolescents with disorders of growth who are at risk for significant co-morbidities and mortality. The symposium will build upon the success of the prior conferences to provide: 1) in depth-discussion and updates on outstanding hot topics, 2) information on ongoing and innovative lines of research, 3) the proper framework for interaction between clinical and basic investigators, and 4) a stimulus for the incorporation of new groups of research and young investigators. Growth retardation is a common result of CKD in childhood and results in failure of the patient to achieve the final adult height consistent with their genetic potential. Despite major advances in our understanding of the cellular and molecular etiologies for the growth abnormalities, as well as, well-defined therapies aimed at preventing or correcting the growth defects, 37% of children with CKD in the North American Pediatric Renal Trials and Collaborative Studies database had statutory growth impairment. Additionally, data from the United States Renal Data System database has demonstrated that patients with severe-to-moderate growth failure had increased hospitalizations rates and increased risk of death. The role of growth impairment in the higher incidence and prevalence of pediatric-onset cardiovascular risk factors in CKD remains to be characterized. With these issues in mind, and the results of the current NIDDK-support Chronic Kidney Disease in Children Cohort Study, an international scientific organizing committee under the guidance of the IPNA, has assembled a distinguished group of investigators with expertise in growth and its regulation in health and disease, in order to convene a three day interactive scientific meeting in Olviedo, Spain, aimed at stimulating new research in the field and facilitating the development of new investigators and trainees. Competitive travel grants will provide the opportunity for their attendance and participation in the meeting with peer-reviewed poster sessions of their research for critical feedback from senior investigators. A website will disseminate meeting information.