Conference on Molecular Biology of Hearing and Deafness

描述(由申请者提供)：请求部分资助，以主办第七届听力和耳聋分子生物学会议。会议将于2009年6月在马萨诸塞州的波士顿举行。会议的目的是：1)促进尚未被广泛应用于听觉系统的新兴分子生物学领域的研究；2)审查与听力和耳聋相关的分子生物学的进展；3)促进从事分子听觉研究的不同实验室之间以及基础科学家和临床医生之间的互动和合作；4)鼓励能够导致听力障碍的诊断和治疗的翻译研究；以及5)通过耳聋遗传学和听力研究的教育，向波士顿地区的患者倡导团体和学校提供外联服务。来自听觉系统以外的演讲者将讨论高通量测序、计算遗传学和HapMap项目的应用、分子进化和疾病图谱、视觉系统分子生物学的最新进展，以及其他主题。听觉会议将包括但不限于：分子遗传学；表观遗传机制；发育；整合基因功能；听力和前庭疾病的分子基础；基因筛选和基因治疗；以及再生。请提供支持，为少数族裔与会者和受训人员提供奖学金，支付一些受邀与会者的旅费，并支持与主办会议有关的其他费用。 项目简介：请求提供部分支持，以主办第七届听力和耳聋分子生物学会议。会议将于2009年6月在马萨诸塞州的波士顿举行。会议的议题包括但不限于：遗传性耳聋的分子遗传学和基因作图；突变异质性和耳聋表型；功能性相关耳聋基因家族；遗传性耳聋的复杂遗传学；听觉发育的分子调控；内耳细胞表型的遗传学；毛细胞转导的分子基础；中枢听觉系统；听觉组织特异性基因活性和表达谱；耳蜗损伤、再生和修复；耳聋突变的分子诊断；耳科疾病的分子生物学：病因和治疗。

DESCRIPTION (provided by applicant): Partial support is requested to host the 7th Conference on the Molecular Biology of Hearing and Deafness. The conference will be held in Boston, MA in June, 2009. The aims of the conference are to: 1) promote research in emerging areas of molecular biology that have not been extensively applied to the auditory system; 2) review progress in molecular biology related to hearing and deafness; 3) facilitate interaction and collaboration between different laboratories engaged in molecular auditory research, as well as between basic scientists and clinicians; 4) encourage translational research that can lead to diagnostics and therapeutics for the treatment of hearing disorders; and 5) provide outreach to patient advocacy groups and schools in the Boston area, with education on the genetics of deafness and hearing research. Speakers from outside of the auditory system will address applications of high-throughput sequencing, computational genetics and the HapMap project, molecular evolution and disease mapping, recent advances in molecular biology of the visual system, as well as additional topics. Auditory sessions will include, but are not limited to: molecular genetics; epigenetic mechanisms; development; integrated gene function; the molecular basis of hearing and vestibular disorders; genetic screening and gene therapy; and regeneration. Support is requested to offer scholarships for minority attendees and trainees, defray the travel costs of some invited participants, and support other costs associated with hosting the conference. Project Narrative: Partial support is requested to host the 7th Conference on the Molecular Biology of Hearing and Deafness. The Conference will be held in Boston, MA in June, 2009. Topics of the Conference include, but are not limited to: molecular genetics and gene mapping of inherited deafness; mutational heterogeneity and deafness phenotypes; families of functionally related deafness genes; complex genetics in inherited deafness; molecular regulation of auditory development; genetics of cell phenotype in the inner ear; molecular basis of hair cell transduction; central auditory system; auditory tissue specific gene activity and expression profilin; cochlear damage, regeneration and repair; molecular diagnostics of deafness mutations; molecular biology of otologic disease: etiology and therapy.