Systems Engineering Design of Room Respiration Calorimeters

描述(申请人提供)：能量失衡是美国的一个主要健康问题，与生活质量低下有关，并增加了几种疾病的风险，包括冠心病、癌症和糖尿病。房间呼吸量热计是长期和高分辨率测量能量消耗和底物氧化的标准。然而，许多生理学家和内科医生并不能使用房间热量计，因为他们必须自己建造。Devicix计划应用严格的系统工程方法来设计一种被验证为可靠和高效的热量计。我们的目标是最大限度地提高性能，最大限度地减少购买、安装和操作房间热量计的财务和运营负担。公共卫生相关性：全身呼吸量热计是研究超重和营养不良的原因和治疗的重要工具。自从100多年前这些热量计首次被使用以来，研究人员就不得不建造自己的热量计。这个实验室到市场的项目将优化性能，降低全身热量计设计的成本，并使其成为商业产品。

DESCRIPTION (provided by applicant): Energy imbalance is a major health problem in the US that is related to poor quality of life and increases the risk of several diseases, including coronary heart disease, cancer and diabetes. Room respiration calorimeters are the standard for long-term and high resolution measurements of energy expenditure and substrate oxidation. Yet, room calorimeters aren't available to many physiologists and physicians who would like to use them because they have to build their own. Devicix plans to apply rigorous systems engineering methods to design a calorimeter that is validated as reliable and efficient. Our goals are to maximize performance and minimize the financial and operational burdens to purchase, install and operate a room calorimeter. PUBLIC HEALTH RELEVANCE: Whole-body respiration calorimeters are an important tool for research into the causes and treatments of overweight and poor nutrition. Ever since these calorimeters were first used more than 100 years ago investigators have had to build their own. This Lab- to-Market project will optimize the performance and reduce the cost of a whole-body calorimeter design and make them available as a commercial product.