Computer-Assisted Cognitive Rehabilitation Intervention for Persons with MS

描述（由申请人提供）：多发性硬化症（MS）对认知的影响，被认为发生在50-75%的MS患者身上，已经越来越多地认识到这是该疾病的主要致残症状之一。虽然许多研究已经解决了多发性硬化症的情绪和身体影响，但很少有人关注可能有助于管理多发性硬化症患者通常经历的认知变化的策略。本研究旨在完善和测试一种新的计算机辅助认知康复干预，MAPSS-MS（多发性硬化症患者的记忆、注意力和问题解决技能）。这种干预的目标是帮助MS患者最大限度地提高他们的认知功能，并发展技能和策略来管理认知限制。MAPSS-MS既有小组成分，也有个人电脑辅助认知康复成分。干预的小组组成部分旨在帮助参与者提高自我效能，以控制MS症状和使用代偿策略。小组干预将与创新的计算机辅助认知康复（CACR）组件配对，该组件可以在参与者家中实施。CACR将帮助个人发展注意力、执行力、记忆力和解决问题的能力。本探索性研究的具体目的是：(1)确定提供MAPPS- MS -一种改善MS患者认知功能的干预措施的可行性；(2)探索“MAPSS-MS”干预对认知表现（一系列神经心理测试）、记忆策略的使用、MS控制的自我效能、日常生活活动的神经心理能力、抑郁症状和感知生活质量的影响；(3)探索参与者对MAPSS-MS干预在日常生活中的可接受性和有用性的感知。干预对结果变量的影响将通过随机临床试验设计进行评估，在66名ms患者的样本中有一个等待名单对照组，研究变量的测量将在基线、2个月（MAPPS干预后立即）和5个月（干预完成后3个月）进行。这项探索性研究的结果将支持未来旨在改善多发性硬化症患者认知功能和生活质量的研究。公共卫生相关性：认知功能障碍对多发性硬化症（MS）患者来说是常见的和致残的。这项拟议的研究将测试一种计算机辅助的认知康复干预，旨在提高日常生活中的认知表现和认知能力。

DESCRIPTION (provided by applicant): The effects of multiple sclerosis (MS) on cognition, thought to occur in 50-75% of persons with MS, have gained increasing recognition as one of the major disabling symptoms of the disease. While numerous studies have addressed the emotional and physical impact of MS, little attention has been given to strategies that might help manage the cognitive changes commonly experienced by persons with MS. The proposed study seeks to refine and test a novel computer-assisted cognitive rehabilitation intervention, MAPSS-MS (Memory, Attention, & Problem Solving Skills for persons with MS). The goal of this intervention is to help persons with MS maximize their cognitive functioning and develop skills and strategies to manage cognitive limitations. The MAPSS-MS has both a group component and an individual computer-assisted cognitive rehabilitation component. The group component of the intervention is designed to help participants improve self-efficacy for control of MS symptoms and use of compensatory strategies. The group intervention will be paired with an innovative computer-assisted cognitive rehabilitation (CACR) component that can be implemented in the participant's home. The CACR will assist individuals to develop attention, executive, memory and problem solving skills. The specific aims of this exploratory study are to: (1) Determine the feasibility of delivering the MAPPS- MS - an intervention to improve cognitive functioning for persons with MS; (2) Explore the effects of the "MAPPS-MS" intervention on cognitive performance (battery of neuropsychological tests), use of memory strategies, self-efficacy for control of MS, neuropsychological competence in activities of daily living, depressive symptoms, and perceived quality of life: and (3) Explore participant perceptions of the acceptability and usefulness of the MAPSS-MS intervention in their daily lives. The effects of the intervention on outcome variables will be assessed using a randomized clinical trial design with a wait list control group in a sample of 66 persons with MS. Measurements of study variables will occur at baseline, at 2 months (immediately after the MAPPS intervention), and at 5 months (3 months after the intervention is complete). Findings from this exploratory study will support future research designed to improve the cognitive functioning and quality of life of persons with MS. PUBLIC HEALTH RELEVANCE: Difficulties with cognitive functioning are common and disabling for persons with multiple sclerosis (MS). The proposed study will test a computer-assisted cognitive rehabilitation intervention that is designed to improve both cognitive performance and cognitive competence for functioning in everyday life.