Movable Equipment for DDB Animal Facility

描述（申请人提供）：本提案的具体目标是：（1）加强南卡罗来纳州医科大学集中管理的动物设施，以支持NIH和其他PHS支持的研究;（2）协助MUSC保持其AAALAC的卓越性-认可的动物护理和使用计划，以及遵守美国农业部动物福利法和DHHS有关实验室护理和使用政策的出色记录动物;以及（3）在新设施中利用通风架为小鼠提供所需的住房，以优化动物的安全性和舒适性，并保护研究和动物护理人员的健康。该预算要求提供资金，用于在南卡罗来纳州医科大学药物发现大楼（MUSC）的一个新动物设施中安装可移动设备（用于容纳人类疾病小鼠模型的通风机架系统）。药物发现大楼（DDB）是MUSC在转化研究方面研究能力的战略扩展。实验动物研究部（DLAR）管理无特定病原体（SPF）环境中的动物护理和使用计划，由机构动物护理和使用委员会（IACUC）进行审查和监督，并自1987年以来获得AAALAC-International的持续全面认证。这些设备将有助于持续遵守美国农业部、PHS和AAALAC国际的所有规定和标准。维持SPF环境并遵守当前和未来的实验动物护理和使用标准，需要达到最高的消毒、净化和职业安全标准。

DESCRIPTION (provided by applicant): The specific aims of this proposal are to: (1) Enhance centrally managed animal facilities at the Medical University of South Carolina to support the conduct of NIH- and other PHS-supported research; (2) Assist MUSC in maintaining the excellence of its AAALAC-accredited animal care and use program and outstanding record of compliance with the USDA Animal Welfare Act and DHHS policies related to care and use of laboratory animals; and (3) Provide needed housing for mice in a new facility utilizing ventilated racks to optimize the safety and comfort of the animals and protect the health of the research and animal care personnel. The budget requests funds for movable equipment (ventilated rack systems to house mouse models of human disease) to be installed in a new animal facility in the Drug Discovery Building at the Medical University of South Carolina (MUSC). The Drug Discovery Building (DDB) is a strategic expansion of MUSC's research capabilities in translational research. The Division of Laboratory Animal Studies (DLAR) manages the animal care and use program in a specific pathogen free (SPF) environment, with review and oversight from the Institutional Animal Care and Use Committee (IACUC) and continuous full accreditation from AAALAC-International since 1987. The equipment will facilitate ongoing compliance with all provisions and standards of the USDA, PHS, and AAALAC-International. Maintaining an SPF environment and remaining in compliance with current and future standards of laboratory animal care and use demand the highest achievable standards of disinfection, decontamination and occupational safety.