Animal Models of Digestive Disease Core

消化系统疾病动物模型核心

• 批准号: 10586114
• 负责人: Suzanne L Craig
• 金额: $ 14.18万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-03 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10586114
• 关键词: American; Animal Experimentation; Animal Model; Animals; Area; Biological Products; Biomedical Research; Caring; Catheters; Cells; Centers of Research Excellence; Chemicals; Cirrhosis; Complex; Core Facility; Data; Diet; Digestive System Disorders; Disease model; Educational workshop; Environment; Extramural Activities; Faculty; Feedback; Fibrosis; Funding; Future; Generations; Genetic; Germ-Free; Gnotobiotic; Housing; Individual; Inflammation; Knowledge; Laboratories; Laboratory Animals; Laboratory mice; Life; Ligation; Liver diseases; Malignant Neoplasms; Medical; Mentors; Mentorship; Metabolic Diseases; Modeling; Modification; Mus; Needs Assessment; Operative Surgical Procedures; Organoids; Osmosis; Partial Hepatectomy; Performance; Procedures; Pump; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; South Carolina; Surveys; Technology; Training; Universities; Update; Work; animal facility; animal resource; bile duct; driving force; experience; follow-up; gastrointestinal system; implantation; in vivo; in vivo Model; meetings; member; microbiome; microbiome research; microorganism; skills; tool

Animal Models of Digestive Disease Core – Project Summary The objective of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enhance research infrastructure and expand research capacity to enable outstanding and collaborative biomedical research in digestive and liver diseases. We wish to establish and sustain the CDLD as the driving force for digestive and liver diseases research at the Medical University of South Carolina (MUSC). We further envision that the MUSC CDLD will become a major focal point for digestive and liver diseases in the state of South Carolina, becoming a hub for trainees and established investigators alike. The topic of this COBRE is particularly relevant given the enormous impact of digestive and liver diseases on a broad range of Americans, including the citizens of South Carolina. Performance of digestive disease research requires utilization of unique and complex models of disease. Thus, we have developed a Core intended to specifically provide the COBRE in Digestive & Liver Diseases (CDLD) with a distinctive, unified, and skilled core facility that provides access to essential animal models and guidance on research project planning and implementation. The proposed core will leverage existing resources and expertise within the MUSC Division of Laboratory Animal Resources (DLAR) in order to efficiently develop new capabilities that focus on producing in vivo models of digestive disease. Core leaders will offer CDLD Junior Investigators (JIs) specialized knowledge, mentorship and training on animal models so that they obtain sufficient, high quality data for their projects, which will then form the basis of their successful competition for future independent extramural funding. Supporting JIs’ research is the a objective for the AMDDC; however, all investigators at MUSC will have access to the models, resources, and training the Core provides. To achieve the stated objective, the AMDDC will be composed of three distinct but interactive components as follows: 1) Animal models of digestive and liver diseases, 2) A gnotobiotics facility, and 3) A focused and extensive training and mentoring component. Members of this core are skilled and highly experienced, supporting the generation of high quality data. !

消化系统疾病动物模型核心-项目摘要 生物医学研究卓越中心（COBRE）在消化和肝脏疾病（CDLD）的目标 是加强研究基础设施，扩大研究能力，使杰出的和合作的 消化和肝脏疾病的生物医学研究。我们希望建立和维持CDLD作为推动 南卡罗来纳州医科大学（MUSC）消化和肝脏疾病研究的力量。我们进一步 设想MUSC CDLD将成为消化和肝脏疾病的主要焦点， 南卡罗来纳州，成为学员和既定调查员的中心。这次COBRE的主题是 考虑到消化系统和肝脏疾病对广大美国人的巨大影响， 包括南卡罗来纳州的市民。 消化系统疾病的研究需要利用独特而复杂的疾病模型。因此，在本发明中， 我们已经开发了一个核心，旨在专门提供消化和肝脏疾病（CDLD）的COBRE 拥有独特、统一和熟练的核心设施，提供基本的动物模型和指导 研究项目的规划和实施。拟议核心资源将利用现有资源， MUSC实验动物资源部（DLAR）的专业知识，以有效地开发新的 专注于生产消化系统疾病的体内模型。核心领导人将提供CDLD初级 研究者（JIs）对动物模型的专业知识，指导和培训，以便他们获得 为他们的项目提供充足、高质量的数据，这将成为他们成功竞争的基础， 未来独立的校外资助。支持JIs的研究是AMDDC的目标;然而，所有 MUSC的研究人员将可以访问核心提供的模型、资源和培训。 为实现上述目标，非洲荒漠化和干旱问题专家会议将由三个不同但相互作用的组成部分组成， 以下：1）消化道和肝脏疾病的动物模型，2）gnotobiotics设施，和3）重点和 广泛的培训和指导部分。这一核心的成员都是熟练和经验丰富的， 支持高质量数据的生成。 !