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Animal Models of Digestive Disease Core

消化系统疾病动物模型核心

基本信息

批准号：
10337322
负责人：
Suzanne L Craig
金额：
$ 21.2万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-03 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337322
关键词：
American Animal Experimentation Animal Model Animals Area Biological Products Biomedical Research Caring Catheters Cells Centers of Research Excellence Chemicals Cirrhosis Complex Core Facility Data Diet Digestive System Disorders Disease model Educational workshop Environment Extramural Activities Faculty Feedback Fibrosis Funding Future Generations Genetic Germ-Free Gnotobiotic Housing Individual Inflammation Knowledge Laboratories Laboratory Animals Laboratory mice Ligation Liver diseases Malignant Neoplasms Medical Mentors Mentorship Metabolic Diseases Modeling Modification Mus Needs Assessment Operative Surgical Procedures Organoids Partial Hepatectomy Performance Procedures Pump Research Research Infrastructure Research Personnel Research Project Grants Resources Services South Carolina Surveys Training Universities Update Work animal facility animal resource base bile duct driving force experience follow-up gastrointestinal system implantation in vivo in vivo Model meetings member microbiome microbiome research microorganism tool

项目摘要

Animal Models of Digestive Disease Core – Project Summary The objective of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enhance research infrastructure and expand research capacity to enable outstanding and collaborative biomedical research in digestive and liver diseases. We wish to establish and sustain the CDLD as the driving force for digestive and liver diseases research at the Medical University of South Carolina (MUSC). We further envision that the MUSC CDLD will become a major focal point for digestive and liver diseases in the state of South Carolina, becoming a hub for trainees and established investigators alike. The topic of this COBRE is particularly relevant given the enormous impact of digestive and liver diseases on a broad range of Americans, including the citizens of South Carolina. Performance of digestive disease research requires utilization of unique and complex models of disease. Thus, we have developed a Core intended to specifically provide the COBRE in Digestive & Liver Diseases (CDLD) with a distinctive, unified, and skilled core facility that provides access to essential animal models and guidance on research project planning and implementation. The proposed core will leverage existing resources and expertise within the MUSC Division of Laboratory Animal Resources (DLAR) in order to efficiently develop new capabilities that focus on producing in vivo models of digestive disease. Core leaders will offer CDLD Junior Investigators (JIs) specialized knowledge, mentorship and training on animal models so that they obtain sufficient, high quality data for their projects, which will then form the basis of their successful competition for future independent extramural funding. Supporting JIs’ research is the a objective for the AMDDC; however, all investigators at MUSC will have access to the models, resources, and training the Core provides. To achieve the stated objective, the AMDDC will be composed of three distinct but interactive components as follows: 1) Animal models of digestive and liver diseases, 2) A gnotobiotics facility, and 3) A focused and extensive training and mentoring component. Members of this core are skilled and highly experienced, supporting the generation of high quality data. !

消化疾病动物模型核心-项目总结