Animal Models of Digestive Disease Core

消化系统疾病动物模型核心--项目总结 消化与肝病生物医学卓越研究中心(COBRE)的目标 是加强研究基础设施和扩大研究能力，以实现杰出和协作 消化和肝脏疾病的生物医学研究。我们希望建立并维持CDLD作为驱动力 南卡罗来纳医科大学(MUSC)消化和肝病研究部队。我们进一步 设想MUSC CDLD将成为该州消化和肝脏疾病的主要焦点 南卡罗来纳州，成为实习生和老牌调查人员的中心。这位科布雷的主题是 尤其是考虑到消化系统和肝脏疾病对广大美国人的巨大影响， 包括南卡罗来纳州的市民。 消化系统疾病研究需要利用独特而复杂的疾病模型。因此， 我们已经开发了一个核心，专门为消化和肝脏疾病(CDLD)提供Cobre 具有独特、统一和熟练的核心设施，可提供基本的动物模型和指导 关于研究项目的规划和实施。拟议的核心将利用现有资源和 南加州大学实验动物资源部(DLAR)内的专业知识，以有效地开发新的 专注于生产消化系统疾病体内模型的能力。核心领导人将向CDLD初级员工提供 研究人员(JIS)在动物模型方面的专业知识、指导和培训，以便他们获得 为他们的项目提供充足、高质量的数据，这些数据将成为他们成功竞争的基础 未来独立的外部资金。支持JIS的研究是AMDDC的一个目标；然而，所有 MUSC的调查人员将可以访问核心提供的模型、资源和培训。 为了实现所述目标，AMDDC将由三个不同但相互作用的部分组成，包括 如下：1)消化和肝脏疾病的动物模型，2)灵知生物研究所，以及3)专注和 广泛的培训和指导部分。这个核心的成员都是熟练的和经验丰富的， 支持生成高质量的数据。 好了！

Animal Models of Digestive Disease Core – Project Summary The objective of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enhance research infrastructure and expand research capacity to enable outstanding and collaborative biomedical research in digestive and liver diseases. We wish to establish and sustain the CDLD as the driving force for digestive and liver diseases research at the Medical University of South Carolina (MUSC). We further envision that the MUSC CDLD will become a major focal point for digestive and liver diseases in the state of South Carolina, becoming a hub for trainees and established investigators alike. The topic of this COBRE is particularly relevant given the enormous impact of digestive and liver diseases on a broad range of Americans, including the citizens of South Carolina. Performance of digestive disease research requires utilization of unique and complex models of disease. Thus, we have developed a Core intended to specifically provide the COBRE in Digestive & Liver Diseases (CDLD) with a distinctive, unified, and skilled core facility that provides access to essential animal models and guidance on research project planning and implementation. The proposed core will leverage existing resources and expertise within the MUSC Division of Laboratory Animal Resources (DLAR) in order to efficiently develop new capabilities that focus on producing in vivo models of digestive disease. Core leaders will offer CDLD Junior Investigators (JIs) specialized knowledge, mentorship and training on animal models so that they obtain sufficient, high quality data for their projects, which will then form the basis of their successful competition for future independent extramural funding. Supporting JIs’ research is the a objective for the AMDDC; however, all investigators at MUSC will have access to the models, resources, and training the Core provides. To achieve the stated objective, the AMDDC will be composed of three distinct but interactive components as follows: 1) Animal models of digestive and liver diseases, 2) A gnotobiotics facility, and 3) A focused and extensive training and mentoring component. Members of this core are skilled and highly experienced, supporting the generation of high quality data. !